Diaminoguanidine derivative treats bacterial infections in farmed animals

ChangeBridge: Patent Grants - Therapeutics (A61P)

Published March 31st, 2026

Detected March 31st, 2026

Summary

USPTO granted patent US12589085B2 to Guangzhou Insighter Biotechnology Co., Ltd. for a diaminoguanidine derivative compound and feed composition for veterinary use in preventing and treating bacterial infections in farmed animals. The patent covers the compound with R1 as C1-C20 alkyl, applications including reproductive system and skin infections, and includes 11 claims.

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What changed

USPTO issued Patent No. US12589085B2 granting Guangzhou Insighter Biotechnology Co., Ltd. exclusive rights to a diaminoguanidine derivative and feed composition for veterinary drug applications. The patent (filed July 22, 2019, Application No. 17627133) covers compounds where R is NO2 or formulas II/III, R1 is C1-C20 alkyl, and applications for treating infectious diseases in farmed animal reproductive systems, skin, and other tissues. The patent includes 11 claims and CPC classifications A61K 31/155, A61P 7/00, A61P 31/04, and A61P 15/00.

No immediate compliance actions are required from the industry. This patent grant establishes IP rights for the assignee and may affect competitive dynamics in the veterinary antibacterial feed additives market. Parties developing similar diaminoguanidine-based veterinary compounds should consider potential infringement implications. The public may access the original document via the USPTO portal.

Source document (simplified)

← USPTO Patent Grants

Use of diaminoguanidine derivative and feed composition thereof in preparation of veterinary drug

Grant US12589085B2 Kind: B2 Mar 31, 2026

Assignee

Guangzhou Insighter Biotechnology Co., Ltd.

Inventors

Xianfeng Peng

Abstract

Disclosed is a use of a diaminoguanidine derivative and a feed composition thereof in the preparation of a veterinary drug. Particularly, disclosed is a use of a diaminoguanidine derivative having a structure of formula (I), or a stereoisomer, geometric isomer, tautomer, solvate, pharmaceutically acceptable salt thereof, or a prodrug thereof, in the preparation of an animal drug for preventing, managing, treating, or alleviating a disease resulting from bacterial infection, wherein R is NO2, or a group represented by formula (II) or formula (III); R1 is a linear or branched C1-C20 alkyl group; A is O, NH or S; R2 is a linear or branched C3-C14 alkyl, C5-C6 cycloalkyl, C5-C6 aryl or CH2(C5-C6 aryl) group. The diaminoguanidine derivative is a non-toxic and safe compound for animals, and is markedly effective in the treatment of infectious diseases in the reproductive system, skin, etc., of farmed animals.