Circular DNA Purification Using Nanoclays
Summary
USPTO published patent application US20260098252A1 by Texas State University (filed October 3, 2025) disclosing a method of purifying circular DNA from samples using nanoclays that preferentially adsorb contaminants including non-circular DNA, RNA, proteins, and endotoxins while leaving circular DNA unbound. The elution-free method separates nanoclay-contaminant complexes from the enriched circular DNA fraction. The invention also covers compositions and systems for such purification and methods of refining nanoclays for the purification process.
What changed
USPTO published a patent application disclosing a method of purifying circular DNA using nanoclays that preferentially adsorb multiple contaminants (non-circular DNA, RNA, proteins, endotoxins) while leaving circular DNA substantially unbound in solution. The elution-free method involves exposing a sample to nanoclay and separating nanoclay-contaminant complexes from the circular DNA fraction. The application also covers compositions, systems, and methods of refining nanoclay materials for this purpose.
For biotech and pharmaceutical companies developing gene therapies, DNA vaccines, or other circular DNA-based products, this patent application signals potential intellectual property considerations for purification technologies. Competitors should monitor prosecution and assess design-around options or licensing opportunities. Researchers in this space should consider this prior art when evaluating freedom-to-operate.
What to do next
- Monitor for patent prosecution updates
- Review for potential licensing or design-around opportunities
Archived snapshot
Apr 13, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
PURIFICATION OF CIRCULAR DNAS FROM CELLS USING NANOCLAYS
Application US20260098252A1 Kind: A1 Apr 09, 2026
Assignee
TEXAS STATE UNIVERSITY
Inventors
Drew Scott Sowersby, Lysle Kevin Lewis
Abstract
Disclosed herein is a method of purifying circular DNA from a sample by exposure of the sample to a nanoclay that preferentially adsorbs multiple contaminants, including non-circular DNA, RNA, proteins, and endotoxins, while leaving circular DNA substantially unbound in solution. The elution-free method also includes a step of separating nanoclay-contaminant complexes from the enriched circular DNA fraction. Also disclosed herein are compositions and systems operable for purifying circular DNA from a sample. Also disclosed herein are methods of refining, formulating or modifying a nanoclay for use in purifying circular DNA from a sample.
CPC Classifications
C12N 15/1006 B01J 20/12 B01J 20/28007 B01J 20/28009 B01J 20/3071
Filing Date
2025-10-03
Application No.
19349595
Named provisions
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