CD38 Antibody Variant Improves Manufacturing Yield
Summary
USPTO granted patent US12600790B2 to Vivasor, Inc. covering a variant anti-CD38 IgG antibody with improved manufacturing yield and a mutated light chain that reduces cleavage heterogeneity. The patent contains 19 claims and is classified under C07K 16/2878 and related CPC codes.
What changed
USPTO granted patent US12600790B2 to Vivasor, Inc. for an anti-CD38 IgG antibody variant with improved manufacturing yield through reduced cleavage heterogeneity. The patent covers the antibody sequence modifications and production methods.
Companies developing CD38-targeted therapeutics should review the claims for potential licensing needs or freedom-to-operate concerns. The 19 granted claims establish enforceable IP rights in the antibody therapeutics space.
What to do next
- Review patent claims for freedom-to-operate implications
- Assess licensing requirements for CD38 antibody development
- Monitor for related patent publications
Archived snapshot
Apr 14, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Variant antibody that binds CD38
Grant US12600790B2 Kind: B2 Apr 14, 2026
Assignee
Vivasor, Inc.
Inventors
Barbara A. Swanson, Heyue Zhou, Jian Cao
Abstract
The present disclosure provides anti-CD38 IgG class antibody having improved ability to be manufactured at higher yields compared to the parent antibody having the original wild type sequence. The present disclosure provides a mutated antibody light chain that reduces cleavage heterogeneity for improved production of a homogeneous population of antibody light chains.
CPC Classifications
C07K 16/2878 C07K 2317/21 C07K 2317/55 C07K 2317/565 C07K 2317/24 C07K 2317/92 C07K 16/2896 A61K 2039/505
Filing Date
2020-12-18
Application No.
17127766
Claims
19
Related changes
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Source
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