5T4 Binding Polypeptides for Cancer Therapy
Summary
USPTO granted patent US12600794B2 to Abdera Therapeutics for 5T4 binding polypeptides useful for cancer therapy. The 36 claims cover polypeptides conjugated to chelating agents or radionuclide complexes. The patent protects compositions and methods for treating 5T4-expressing cancers.
What changed
USPTO granted patent US12600794B2 to Abdera Therapeutics for compositions comprising 5T4 binding polypeptides useful for cancer therapy. The patent covers 36 claims including unconjugated polypeptides and those conjugated to chelating agents or radionuclide complexes for targeted cancer treatment.
For pharmaceutical and biotech companies developing 5T4-targeting cancer therapeutics, this patent establishes intellectual property protection that may affect freedom-to-operate considerations. Companies pursuing radiopharmaceutical or immunotherapy approaches targeting 5T4 antigens should evaluate potential licensing needs or design-around strategies.
What to do next
- Monitor for related patent family filings
- Review freedom-to-operate implications for 5T4-targeting therapeutics
Archived snapshot
Apr 14, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
5T4 binding polypeptides and uses thereof
Grant US12600794B2 Kind: B2 Apr 14, 2026
Assignee
ABDERA THERAPEUTICS INC.
Inventors
Alexander Laurence Mandel, Raja Solomon Viswas, Adam Daniel Judge, Michael J. Abrams, Emma Jane Cummins, Brandon Robert McLeod, Iva Kulic, Douglas Bruce MacKay
Abstract
Described herein are polypeptides that bind to 5T4 useful for cancer therapy. Further disclosed herein are polypeptides that bind to 5T4 that are conjugated to a chelating agent or a radionuclide complex thereof.
CPC Classifications
C07K 16/30 C07K 2317/53 C07K 2317/565 C07K 2317/569 C07K 2317/71 C07K 2317/94 A61K 51/1045 A61K 51/1096 A61K 2121/00 A61K 2123/00 A61P 35/00
Filing Date
2025-07-21
Application No.
19275203
Claims
36
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Source
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