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Cardiac Myosin Inhibitor Aficamten for Hypertrophic Cardiomyopathy

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Cardiac Myosin Inhibitor Aficamten for Hypertrophic Cardiomyopathy

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Apr 10, 2026

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METHODS FOR TREATING HYPERTROPHIC CARDIOMYOPATHY

Application US20260097021A1 Kind: A1 Apr 09, 2026

Inventors

Fady MALIK, Stuart KUPFER, Stephen B. HEITNER, Laura Ann ROBERTSON, Lixin MENG, Anna OSMUKHINA, Qi WOHLTMAN

Abstract

Methods for treating obstructive hypertrophic cardiomyopathy are described herein. The treatment methods include the administration of a cardiac myosin inhibitor (CK-3773274, also referred to as CK-274 or aficamten) and may include titrating an administrated daily dose based on one or more components of an echocardiogram. The daily dose may be increased, maintained, decreased, or terminated, based on the echocardiogram.

CPC Classifications

A61K 31/4245 A61P 9/00 A61P 9/06

Filing Date

2025-07-01

Application No.

19257352

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