Tricyclic KRAS Inhibitor Patent - Incyte Corporation
Summary
The USPTO granted Patent US12600717B2 to Incyte Corporation on April 14, 2026 for tricyclic compounds as inhibitors of KRAS activity. The patent contains 34 claims covering Formula I compounds useful in treating diseases associated with KRAS activity, including cancer. Filing date was July 13, 2022, under application number 17812310.
What changed
USPTO granted Incyte Corporation Patent US12600717B2 for tricyclic KRAS inhibitor compounds effective April 14, 2026. The patent contains 34 claims under CPC classification C07D 471/04 and covers Formula I compounds useful in treating KRAS-associated diseases including cancer. Inventors include Zhenwu Li, Zhiyong Yu, Jeremy Roach, and nine others. Filing date was July 13, 2022 under application 17812310.
Pharmaceutical companies developing KRAS-targeted cancer therapies should monitor this patent to assess potential freedom-to-operate considerations. The patent grants Incyte exclusive rights to these tricyclic compounds for the duration of the patent term.
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Apr 15, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Tricyclic compounds as inhibitors of KRAS
Grant US12600717B2 Kind: B2 Apr 14, 2026
Assignee
Incyte Corporation
Inventors
Zhenwu Li, Zhiyong Yu, Jeremy Roach, Gia Hoang, Bin Hu, Gencheng Li, Rory McAtee, Ken Mukai, Rocco Policarpo, Robert Susick, Xiaozhao Wang, Wenqing Yao
Abstract
Disclosed are compounds of Formula I (shown below), methods of using the compounds for inhibiting KRAS activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with KRAS activity such as cancer.
CPC Classifications
C07D 471/04
Filing Date
2022-07-13
Application No.
17812310
Claims
34
Named provisions
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