Cμ4 Region for Multi-Specific Antibody Chain Pairing
Summary
USPTO published patent application US20260098094A1 assigned to DNA Twopointo, Inc. covering multi-specific antibodies with IgM Cμ4 region pairing domains for correct heavy and light chain pairing. The invention promotes correct chain combinations and disfavors incorrect pairings in bispecific antibodies. The application was filed November 21, 2025.
What changed
USPTO published patent application US20260098094A1 for Cμ4 region-based chain pairing in multi-specific antibodies assigned to DNA Twopointo, Inc. The patent covers engineered antibodies where IgM Cμ4 region pairing domains promote correct heavy and light chain associations and reduce incorrect combinations.
This patent publication is informational and does not create compliance obligations. Parties developing bispecific antibody therapeutics may wish to review for potential freedom-to-operate implications or licensing opportunities. The technical scope is specific to IgM Cμ4 domain engineering for chain pairing.
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Apr 12, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Cµ4 REGION FOR PAIRING HEAVY AND LIGHT CHAINS IN MULTI-SPECIFIC ANTIBODIES
Application US20260098094A1 Kind: A1 Apr 09, 2026
Assignee
DNA Twopointo, Inc.
Inventors
Jeremy Minshull, Sridhar Govindarajan
Abstract
The invention provides multi-specific, for example bispecific, antibodies which include two different pairs of heavy and light chains, in which directed correct pairing of heavy and light chains is promoted by inclusion of an IgM Cμ4 region pairing domain, or a modified IgM Cμ4 region pairing domain. The IgM Cμ4 region pairs with a light chain kappa region or a CH1 region in one of the pairings. The other pairing is optionally a conventional CH1 and light chain constant region, or can be another pair of engineered binding domains. The IgM Cμ4 region and kappa or CH1 region preferentially associate with one another in the first pairing, and optionally, CH1 and light chain constant regions preferentially associate with each other in the other pairing thereby promoting correct combinations of heavy and light chain and disfavoring incorrect combinations.
CPC Classifications
C07K 16/2827 C07K 16/22 C07K 2317/31 C07K 2317/33 C07K 2317/522 C07K 2317/524 C07K 2317/526 C07K 2317/53 C07K 2317/72 C07K 2317/94
Filing Date
2025-11-21
Application No.
19396664
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