Broad Institute Gene Editing Patent for SMA Treatment
Summary
The USPTO published patent application US20260091141A1 by Broad Institute, Inc. covering gene editing methods, systems, and compositions for treating spinal muscular atrophy (SMA). The application (No. 19288071) was filed on August 1, 2025, and made publicly available on April 2, 2026. Inventors include David R. Liu, Mandana Arbab, and Zaneta Matuszek. The application covers modified messenger RNAs and delivery methods for treating microbial infections or improving subject health.
What changed
The USPTO published a patent application by Broad Institute disclosing gene editing compositions and methods for treating spinal muscular atrophy. The application claims modified messenger RNAs and delivery systems for introducing biological moieties into cells to reduce microorganism growth or improve subject health. CPC classifications include A61K 48/0066, C12N 9/226, C12N 15/11, and C12N 2310/20.
Patent application publications are informational notices establishing priority dates and public disclosure. They do not create immediate compliance obligations. Entities developing gene therapies or gene editing technologies should review the published claims to assess potential freedom-to-operate concerns. No response or action is required by filing date.
Archived snapshot
Apr 2, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
GENE EDITING METHODS, SYSTEMS, AND COMPOSITIONS FOR TREATING SPINAL MUSCULAR ATROPHY
Application US20260091141A1 Kind: A1 Apr 02, 2026
Assignee
The Broad Institute, Inc.
Inventors
David R. Liu, Mandana Arbab, Zaneta Matuszek
Abstract
Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to kill or reduce the growth of microorganisms. Such compositions and methods include the use of modified messenger RNAs, and are useful to treat or prevent microbial infection, or to improve a subject's heath or wellbeing.
CPC Classifications
A61K 48/0066 C12N 9/226 C12N 15/11 C12N 2310/20
Filing Date
2025-08-01
Application No.
19288071
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