Bifunctional compounds for degrading BTK via ubiquitin pathway
Summary
The USPTO has granted patent US12582722B2 to Nurix Therapeutics, Inc. for bifunctional compounds designed to degrade Bruton's tyrosine kinase (BTK) through the ubiquitin proteolytic pathway. The patent covers novel compounds and pharmaceutical compositions for treating various diseases.
What changed
The United States Patent and Trademark Office (USPTO) has granted patent US12582722B2 to Nurix Therapeutics, Inc. This patent covers bifunctional compounds that degrade BTK via the ubiquitin proteolytic pathway, along with related pharmaceutical compositions and methods of use for treating various diseases. The patent was filed on February 4, 2020, and granted on March 24, 2026, with 21 claims.
This grant represents a new intellectual property asset for Nurix Therapeutics, Inc. in the field of targeted protein degradation. While this is a patent grant and not a regulatory rule, it signifies a new therapeutic approach that may eventually lead to new drug development. Compliance officers in the pharmaceutical sector should be aware of this patent as it pertains to novel drug candidates and potential future market exclusivity for treatments involving BTK degradation.
Source document (simplified)
Bifunctional compounds for degrading BTK via ubiquitin proteosome pathway
Grant US12582722B2 Kind: B2 Mar 24, 2026
Assignee
NURIX THERAPEUTICS, INC.
Inventors
Daisuke Kato, Zef Konst, Jeffrey Mihalic, Daniel W. Robbins, Arthur T. Sands
Abstract
The present invention relates to compounds useful for degrading BTK via a ubiquitin proteolytic pathway. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
CPC Classifications
A61K 47/55 A61K 47/545 A61K 47/54 A61P 35/00
Filing Date
2020-02-04
Application No.
17430721
Claims
21
Named provisions
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