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Bifunctional compounds for degrading BTK via ubiquitin pathway

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Published March 24th, 2026
Detected March 24th, 2026
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Summary

The USPTO has granted patent US12582722B2 to Nurix Therapeutics, Inc. for bifunctional compounds designed to degrade Bruton's tyrosine kinase (BTK) through the ubiquitin proteolytic pathway. The patent covers novel compounds and pharmaceutical compositions for treating various diseases.

What changed

The United States Patent and Trademark Office (USPTO) has granted patent US12582722B2 to Nurix Therapeutics, Inc. This patent covers bifunctional compounds that degrade BTK via the ubiquitin proteolytic pathway, along with related pharmaceutical compositions and methods of use for treating various diseases. The patent was filed on February 4, 2020, and granted on March 24, 2026, with 21 claims.

This grant represents a new intellectual property asset for Nurix Therapeutics, Inc. in the field of targeted protein degradation. While this is a patent grant and not a regulatory rule, it signifies a new therapeutic approach that may eventually lead to new drug development. Compliance officers in the pharmaceutical sector should be aware of this patent as it pertains to novel drug candidates and potential future market exclusivity for treatments involving BTK degradation.

Source document (simplified)

← USPTO Patent Grants

Bifunctional compounds for degrading BTK via ubiquitin proteosome pathway

Grant US12582722B2 Kind: B2 Mar 24, 2026

Assignee

NURIX THERAPEUTICS, INC.

Inventors

Daisuke Kato, Zef Konst, Jeffrey Mihalic, Daniel W. Robbins, Arthur T. Sands

Abstract

The present invention relates to compounds useful for degrading BTK via a ubiquitin proteolytic pathway. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

CPC Classifications

A61K 47/55 A61K 47/545 A61K 47/54 A61P 35/00

Filing Date

2020-02-04

Application No.

17430721

Claims

21

View original document →

Named provisions

Abstract Claims

Classification

Agency
USPTO
Published
March 24th, 2026
Instrument
Notice
Legal weight
Non-binding
Stage
Final
Change scope
Minor
Document ID
US12582722B2

Who this affects

Applies to
Drug manufacturers Pharmaceutical companies
Industry sector
3254 Pharmaceutical Manufacturing
Activity scope
Drug Discovery Therapeutic Development
Geographic scope
United States US

Taxonomy

Primary area
Pharmaceuticals
Operational domain
R&D
Compliance frameworks
FDA 21 CFR Part 11 GxP
Topics
Drug Discovery Intellectual Property

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