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Patent Application: Benzamide Compounds for SARS-CoV-2 PLpro Inhibition

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Published August 19th, 2025
Detected March 26th, 2026
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Summary

The USPTO has published a new patent application (US20260085063A1) detailing benzamide compounds and methods for inhibiting SARS-CoV-2 PLpro. The application was filed on August 19, 2025, by inventors Jun Wang, Bin Tan, and Prakash Daulat Jadhav.

What changed

This document is a publication of a United States patent application, specifically US20260085063A1, filed on August 19, 2025. The application describes novel benzamide compounds and their use in inhibiting the SARS-CoV-2 papain-like protease (PLpro), aiming to promote antiviral effects and treat viral infections. The inventors listed are Jun Wang, Bin Tan, and Prakash Daulat Jadhav.

As this is a patent application, it does not impose immediate regulatory obligations or compliance deadlines on regulated entities. However, it signifies potential future intellectual property rights and may influence research and development in the pharmaceutical sector. Companies operating in this space should monitor the progress of this patent application and related filings for potential licensing opportunities or competitive landscape shifts.

Source document (simplified)

← USPTO Patent Applications

BENZAMIDE COMPOUNDS AND METHODS OF USE THEREOF

Application US20260085063A1 Kind: A1 Mar 26, 2026

Inventors

Jun Wang, Bin Tan, Prakash Daulat Jadhav

Abstract

The present disclosure relates, in part, to SARS-CoV-2 papain-like protease (PLpro) inhibitor compounds of Formula (I), pharmaceutical compositions thereof, and methods of using the same for promoting an antiviral effect in a subject and/or treating, preventing, and/or ameliorating a viral infection in a subject:

CPC Classifications

C07D 403/14 A61K 31/4155 A61K 31/427 A61K 31/438 A61K 31/454 A61K 31/496 A61K 31/4995 A61K 31/5377 A61K 31/541 A61P 31/14 C07D 231/12 C07D 401/14 C07D 403/10 C07D 405/14 C07D 413/14 C07D 417/10 C07D 471/10 C07D 487/04 C07D 487/08

Filing Date

2025-08-19

Application No.

19304124

View original document →

Named provisions

Inventors Abstract Filing Date Application No.

Classification

Agency
USPTO
Published
August 19th, 2025
Instrument
Notice
Legal weight
Non-binding
Stage
Draft
Change scope
Minor
Document ID
US20260085063A1

Who this affects

Applies to
Drug manufacturers Pharmaceutical companies
Industry sector
3254 Pharmaceutical Manufacturing
Activity scope
Drug Development Antiviral Therapy
Geographic scope
United States US

Taxonomy

Primary area
Pharmaceuticals
Operational domain
Legal
Compliance frameworks
FDA 21 CFR Part 11
Topics
Intellectual Property Public Health

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