Expression Control Using a Regulatable Intron
Summary
The USPTO granted patent US12600969B2 to Askbio Inc. on April 14, 2026, covering gene expression regulation using regulatory nucleic acid sequences responsive to the unfolded protein response (UPR). The patent includes 14 claims for regulatable introns and UPR-inducible promoters in recombinant expression constructs. This patent grant does not create compliance obligations.
What changed
The USPTO issued patent US12600969B2 to Askbio Inc. for expression control using a regulatable intron responsive to the unfolded protein response. The patent covers recombinant expression constructs with UPR-inducible promoters and regulatory nucleic acid sequences, with 14 claims granted.
Affected parties including biotech companies, pharmaceutical developers, and investors should monitor this IP for potential licensing opportunities or competitive implications in gene therapy and recombinant protein expression applications.
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Apr 15, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Expression control using a regulatable intron
Grant US12600969B2 Kind: B2 Apr 14, 2026
Assignee
Askbio Inc.
Inventors
Graham Whyteside
Abstract
The present invention relates to the use of a regulatory nucleic acid sequences that are able to regulate gene expression in eukaryotic cells and which are responsive to the unfolded protein response (UPR). There are disclosed regulatable introns and UPR-inducible promoters, which are able to regulate gene expression. There are also disclosed recombinant expression constructs comprising such regulatory nucleic acid sequences, whereby expression of the encoded expression product can be induced by invoking the unfolded protein response (UPR) in a eukaryotic cell containing the construct, methods of using such constructs and associated vectors, cells and suchlike.
CPC Classifications
C12N 15/113
Filing Date
2022-11-04
Application No.
17981146
Claims
14
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