6-Aryl Isoindolin-1-ones mGlu2 Modulators, Apr 09

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NEGATIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR 2

Application US20260098030A1 Kind: A1 Apr 09, 2026

Inventors

Craig W. Lindsley, Darren W. Engers, Jeremy S. Coleman, Upendra Rathnayake, Rory A. Capstick

Abstract

Described are 6-aryl isoindolin-1-ones as negative allosteric modulators of metabotropic glutamate receptor 2 (mGlu2), pharmaceutical compositions including the compounds, and methods of using the compounds and compositions for treating depression, anxiety, obsessivecompulsive disorder, cognitive disorders, Alzheimer's disease, or autism spectrum disorders in a subject.

CPC Classifications

C07D 403/04 A61K 31/4035 A61K 31/404 A61K 31/4155 A61K 31/416 A61K 31/4178 A61K 31/4184 A61K 31/4192 A61K 31/422 A61K 31/423 A61K 31/4245 A61K 31/427 A61K 31/428 A61K 31/437 A61K 31/4439 A61K 31/454 A61K 31/4709 A61K 31/4725 A61K 31/496 A61K 31/501 A61K 31/506 A61K 31/5377 A61K 31/541 C07B 59/002 C07D 209/46 C07D 401/04 C07D 403/06 C07D 403/10 C07D 403/12 C07D 405/04 C07D 405/14 C07D 413/04 C07D 413/10 C07D 417/04 C07D 417/12 C07D 471/04

Filing Date

2023-09-15

Application No.

19111910

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