Hydrogels for in situ-forming tissue constructs

ChangeBridge: Patent Grants - Prosthetics (A61F)

Published March 31st, 2026

Detected March 31st, 2026

Summary

USPTO granted Patent US12589188B2 to The Board of Trustees of the Leland Stanford Junior University covering compositions and methods for corneal hydrogel tissue constructs using in situ-forming IPN and semi-IPN hydrogels for lamellar and defect reconstruction of corneal stromal tissue. The patent names eight inventors including David Myung and Sarah Heilshorn, contains 19 claims, and issued March 31, 2026.

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What changed

USPTO issued Patent US12589188B2 to Stanford University on March 31, 2026, covering corneal hydrogel compositions and methods for in situ-forming tissue constructs. The patent specifically addresses interpenetrating network (IPN) and semi-IPN hydrogels designed for lamellar and defect reconstruction of corneal stromal tissue, with 19 claims assigned to eight named inventors.

This is a routine patent grant announcement that conveys exclusive intellectual property rights to Stanford University for commercialization of the described corneal hydrogel technology. It does not impose regulatory compliance requirements on other entities. Patent holders may choose to enforce their exclusive rights against potential infringers through separate legal action.

Source document (simplified)

← USPTO Patent Grants

Hydrogels for in situ-forming tissue constructs

Grant US12589188B2 Kind: B2 Mar 31, 2026

Assignee

The Board of Trustees of the Leland Stanford Junior University

Inventors

David Myung, Fang Chen, Gabriella Fernandes-Cunha, Sarah Hull, Sarah Heilshorn, Christopher Lindsay, Christopher Madl, Hyun Jong Lee

Abstract

Compositions and methods are provided for lamellar and defect reconstruction of corneal stromal tissue using biomaterials that form a defined hydrogel structure in situ, including interpenetrating (IPN) and semi-IPN hydrogels.

CPC Classifications

A61F 13/01029 A61F 2/0036 A61F 2002/30004 A61F 2002/30069 A61F 2002/30133 A61F 2002/30383 A61F 2002/30387 A61F 2002/30507 A61F 2002/30581 A61F 2002/30754 A61F 2002/3082 A61F 2002/4628 A61F 2230/0015 A61F 2250/0014 A61F 13/01025 A61F 13/01038 A61F 13/0209 A61F 13/2025 A61F 13/2042 A61F 13/2051 A61F 13/2068 A61F 13/2071 A61F 13/266 A61F 13/34 A61F 2/4425 A61F 2002/30131 A61F 2002/30586 A61F 2002/30593 A61F 2013/00161 A61F 2013/00182 A61F 2013/00272 A61F 2013/00306 A61F 2013/00387 A61F 2013/00846 A61F 2013/15073 A61F 2013/4593 A61F 2230/0013 A61F 2230/0017 A61F 2230/0023 A61F 2230/0069 A61F 2/00 A61F 2/1648 A61F 2/90 A61F 2/92 A61F 2002/072 A61F 2002/30405 A61F 2002/30451 A61F 2002/30471 A61F 2002/30604 A61F 2002/30677 A61F 2002/4629 A61F 2220/0058 A61F 2220/0091 A61F 2230/0071 A61F 2250/0003 A61F 5/4404 A61F 5/443 A61F 5/445 A61F 13/2022 A61F 2/0077 A61F 2/141 A61F 2/1601 A61F 2/1627 A61F 2/24 A61F 2/3099 A61F 2/3877 A61F 2/484 A61F 2/7812 A61F 2/80 A61F 2/885 A61F 2/91 A61F 2/954 A61F 2002/0068 A61F 2002/065 A61F 2002/1683 A61F 2002/169 A61F 2002/30148 A61F 2002/30153 A61F 2002/30156 A61F 2002/30242 A61F 2002/30398 A61F 2002/30476 A61F 2002/4445 A61F 2002/4622 A61F 2002/4627 A61F 2002/807 A61F 2013/0068 A61F 2230/0019 A61F 2310/00011 A61F 2310/00173 A61F 2310/00407 A61F 2310/00976 A61F 13/0206 A61F 13/0246 A61F 13/42 A61F 2002/16905 A61F 2002/2817 A61F 2002/30171 A61F 2002/30179 A61F 2002/30224 A61F 2002/30365 A61F 2002/30367 A61F 2002/30571 A61F 2002/30578 A61F 2002/30841 A61F 2002/445 A61F 2009/00872 A61F 2013/00119 A61F 2210/00 A61F 2230/005 A61F 2230/0058 A61F 2230/0067 A61F 2250/0058 A61F 9/008 A61F 9/04 A61F 13/02 A61F 13/022 A61F 2/022 A61F 2/08 A61F 2/0811 A61F 2/1616 A61F 2/20 A61F 2/2418 A61F 2/30744 A61F 2/30771 A61F 2/44 A61F 2002/075 A61F 2002/0852 A61F 2002/0888 A61F 2002/30225 A61F 2002/30354 A61F 2002/30495 A61F 2002/30594 A61F 2002/30766 A61F 2002/30914 A61F 2002/4685 A61F 2009/00865 A61F 2250/0023 A61F 2250/0024 A61F 2250/0069 A61F 2310/00389 A61F 13/01012 A61F 13/84 A61F 15/001 A61F 2/0009 A61F 2/062 A61F 2/30988 A61F 2/86 A61F 2/88 A61F 2/915 A61F 2002/009 A61F 2002/0894 A61F 2002/1689 A61F 2002/30011 A61F 2002/30031