Patent Grant: Minimally Invasive Histotripsy Systems and Methods

ChangeBridge: Patent Grants - Diagnosis & Surgery (A61B)

Published March 24th, 2026

Detected March 26th, 2026

Summary

The USPTO has granted a patent (US12582848B2) to The Regents of the University of Michigan for minimally invasive histotripsy systems and methods. The patent covers devices insertable endoscopically or laparoscopically for targeted tissue therapy.

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What changed

The United States Patent and Trademark Office (USPTO) has issued patent grant US12582848B2 for "Minimally invasive histotripsy systems and methods." The patent, assigned to The Regents of the University of Michigan, details devices that can be inserted into a patient endoscopically or laparoscopically to deliver histotripsy therapy to target tissues. Key specifications include a transducer array with a focal length of 10-40 mm, a diameter under 35 mm, and the capability to generate a peak negative focal pressure of at least 20 MPa.

This patent grant signifies a new intellectual property right for a specific medical technology. While not creating direct compliance obligations for other entities, it establishes exclusive rights for the assignee. Companies operating in the medical device or therapeutic technology sectors, particularly those developing or considering histotripsy or similar non-invasive tissue ablation technologies, should be aware of this patent to avoid potential infringement. The filing date for this application was April 7, 2022.

Source document (simplified)

← USPTO Patent Grants

Minimally invasive histotripsy systems and methods

Grant US12582848B2 Kind: B2 Mar 24, 2026

Assignee

The Regents of the University of Michigan

Inventors

Zhen Xu, Timothy Lewis Hall, Greyson Stocker, Man Zhang

Abstract

Minimally invasive histotripsy systems and methods are provided. In some embodiments, a minimally invasive histotripsy device is inserted into a patient. The device can be inserted endoscopically through a natural orifice of the patient, or laparoscopically through an incision in the patient's skin. The minimally invasive histotripsy device can be advanced to the target tissue and acoustically coupled to the target tissue before applying histotripsy therapy to the target tissue. In some embodiments, the minimally invasive histotripsy device includes a transducer array with a focal length of approximately 10-40 mm, a diameter of less than 35 mm, and the ability to create a peak negative focal pressure of at least 20 MPa.

CPC Classifications

A61N 7/00 A61N 2007/0039 A61N 2007/0043 A61N 7/02 A61N 7/022 A61N 2007/0078 A61N 2007/0095 A61B 8/12 A61B 8/4281 A61B 8/085 A61B 8/4477 A61B 8/4488 A61B 8/4494 A61B 2017/22028 A61B 2017/22062 A61B 2090/3784 A61B 17/2202 A61B 2017/22008