Alternate dose regimen identification system

ChangeBridge: Patent Grants - Health Informatics (G16H)

Published March 31st, 2026

Detected March 31st, 2026

Summary

USPTO granted patent US12592303B2 to Express Scripts Strategic Development, Inc. covering methods and systems for dose regimen modification that optimize medication dosing and reduce drug waste. The system receives prescription data, determines drug waste amounts using a predictive model, and identifies alternate medication regimens maintaining efficacy while minimizing waste, triggering notifications for healthcare providers.

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What changed

USPTO granted patent US12592303B2 to Express Scripts Strategic Development, Inc. (inventors: Lesley A. D'Albini, William J. Wright, Sid Phadke, Mark Jacob, Mary M. Dorholt) for an alternate dose regimen identification system. The patent covers operations including receiving prescription data with medication regimen information (dose and interval), using a model to determine drug waste amounts, comparing waste against threshold values, and identifying alternate medication regimens with lower waste while maintaining equivalent treatment efficacy. The system triggers notifications for the alternate regimen.

This patent grant does not create compliance obligations or deadlines for regulated entities. Healthcare organizations, pharmacy benefit managers, and pharmaceutical companies involved in medication management systems may wish to review this intellectual property when developing or licensing dosing optimization technology to understand potential patent landscape considerations.

Source document (simplified)

← USPTO Patent Grants

Alternate dose regimen identification system

Grant US12592303B2 Kind: B2 Mar 31, 2026

Assignee

Express Scripts Strategic Development, Inc.

Inventors

Lesley A. D'Albini, William J. Wright, Sid Phadke, Mark Jacob, Mary M. Dorholt

Abstract

Methods and systems for performing dose regimen modification are provided. The methods and systems perform operations comprising: receiving prescription related data for treating a patient with an expected level of efficacy, the prescription related data comprising medication regimen information including dose and interval; determining, using a model, a first amount of drug waste based on the prescription related data; comparing the first amount of drug waste to a threshold value; and in response to determining that the first amount of drug waste transgresses the threshold value, identifying an alternate medication regimen that is associated with a treatment having a given level of efficacy corresponding to the expected level of efficacy, the alternate medication regimen being associated with a second amount of drug waste that is lower than the first amount of drug waste; and triggering a notification associated with the alternate medication regimen.