WISE Trial: Therapist-Supervised Wrist Exercise vs Usual Care for Fracture Recovery
Summary
NIH registered Clinical Trial NCT07538323, the WISE (Wrist Injury Strengthening Exercise) study, a randomized controlled trial comparing therapist-supervised exercise therapy against usual care self-management advice for adults aged 50 and older recovering from wrist fractures. The trial will measure pain and functional improvement using the Patient Rated Wrist Evaluation questionnaire at 6 months post-injury. Participants receive either supervised therapy sessions (one 60-minute session plus two 30-minute sessions) plus usual-care advice, or usual-care advice alone.
What changed
NIH posted a clinical trial registration for the WISE study on ClinicalTrials.gov. The trial will enroll adults aged 50+ with distal radius or wrist fractures and randomize them to either a therapist-supervised exercise program (plus usual-care advice) or usual-care advice alone. The primary outcome measure is the Patient Rated Wrist Evaluation questionnaire at 6 months.
Healthcare providers and clinical investigators involved in musculoskeletal rehabilitation research should note this trial's design as it may inform future evidence-based practice guidelines for post-fracture care in older adults.
Archived snapshot
Apr 20, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Wrist Injury Strengthening Exercise (WISE) Versus Usual Care Advice for Improving Pain and Function
N/A NCT07538323 Kind: NA Apr 20, 2026
Abstract
The goal of this clinical trial is to find out whether a therapist-guided exercise program helps people aged 50 and older recover better, in terms of pain and function, after a wrist fracture, compared to the usual care advice they would normally receive. The main question it aims to answer is:
• Will participants who receive a therapist-supervised exercise program have better improvement in pain and function, as measured by the Patient Rated Wrist Evaluation questionnaire, six months after their injury?
Researchers will compare these participants with those who receive usual care, which includes advice on self-management, to see if the supervised exercise program leads to greater recovery.
Participants will:
- Either receive supervised exercise, with a therapy session of up to 60 minutes and two additional sessions of up to 30 minutes each in addition to usual-care, or they will receive solely usual-care, consisting of advice on self-management.
- Complete questionnaires electronically at baseline, 3-months, and 6-months.
Conditions: Distal Radius Fracture, Colles Fracture, Wrist Fracture, Wrist Fractures, Fracture Arm
Interventions: Supervised Exercise, Usual Care
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