US12606640B2 - Recombinant Antimicrobial Polypeptide
Summary
The USPTO granted US Patent US12606640B2 to IRTA, Institut de Recerca i Transferència Agroalimentàries, covering a recombinant antimicrobial multidomain polypeptide comprising at least three peptidic domains — a non-enzymatic antimicrobial domain, a bacterial binding domain, and an enzymatic antimicrobial domain. The patent contains 21 claims and was filed on February 18, 2020.
What changed
The USPTO issued Patent US12606640B2 to IRTA, Institut de Recerca i Transferència Agroalimentàries, covering a recombinant antimicrobial multidomain polypeptide produced in inclusion bodies with broad-spectrum antimicrobial activity. The patent names Elena Garcia Fruitos, Anna Aris Giralt, Ramon Roca Pinilla, and Adria Lopez Cano as inventors and contains 21 claims.
Pharmaceutical and biotechnology companies developing antimicrobial peptide therapeutics should review this granted patent for potential freedom-to-operate considerations, as the three-domain structure described may overlap with their own research programmes.
Archived snapshot
Apr 21, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Recombinant antimicrobial multidomain polypeptide, methods of producing and uses thereof
Grant US12606640B2 Kind: B2 Apr 21, 2026
Assignee
IRTA, INSTITUT DE RECERCA I TRANSFERÈNCIA AGROALIMENTÀRIES
Inventors
Elena Garcia Fruitos, Anna Aris Giralt, Ramon Roca Pinilla, Adria Lopez Cano
Abstract
A novel recombinant antimicrobial multidomain polypeptide in an aggregated and functional format is provided. The antimicrobial multidomain polypeptide comprises at least three peptidic domains: a) a non-enzymatic antimicrobial peptidic domain from mammal's immune system, b) a bacterial binding peptidic domain which interacts with the bacterial cell wall or membrane, and c) an enzymatic antimicrobial peptidic domain from mammal's immune system. The antimicrobial multidomain polypeptide exhibits a broad-spectrum antimicrobial effect and is produced in an efficient production system, i.e in form of inclusion bodies.
CPC Classifications
C07K 19/00 C07K 2319/50 C07K 2319/33 C07K 2319/035 C07K 2319/21 C12N 15/63 A61K 38/00
Filing Date
2020-02-18
Application No.
17432474
Claims
21
Mentioned entities
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