Aerobic Exercise Trial for Advanced MS, 12 Weeks, NCT07546721
Summary
NIH has registered a Phase 2 interventional study (NCT07546721) evaluating the feasibility of a 12-week moderate-intensity aerobic exercise program for adults with advanced multiple sclerosis who are wheelchair users. The study will enroll participants for twice-weekly supervised exercise sessions in a research setting, with outcomes assessed at baseline (0 weeks), mid-intervention (6 weeks), post-intervention (12 weeks), and follow-up (24 weeks). Primary endpoints include feasibility measures, safety, and acceptability; secondary endpoints include aerobic fitness, daily function, cognition, fatigue, pain, and sensation. Participants' experiences with the intervention will also be documented.
“The goal of this interventional study is to test the feasibility of 12 weeks of aerobic exercise for people with advanced multiple sclerosis (i.e., wheelchair users).”
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What changed
NIH registered a new interventional clinical trial (NCT07546721) on ClinicalTrials.gov. The study will test whether a 12-week moderate-intensity aerobic exercise program delivered twice weekly in a supervised research setting is feasible for adults with advanced multiple sclerosis who are wheelchair users.
Healthcare providers, researchers, and patients with advanced MS should note that this trial represents emerging evidence on exercise-based interventions for severely impaired MS populations. While the study findings will not establish clinical practice standards directly, positive outcomes regarding feasibility and safety could inform future rehabilitation protocols for this population. The trial's structured outcome assessments across four timepoints (0, 6, 12, and 24 weeks) may yield data useful for MS clinical care and research programs.
Archived snapshot
Apr 23, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Exercise Training for People With Advanced Multiple Sclerosis
N/A NCT07546721 Kind: NA Apr 23, 2026
Abstract
The goal of this interventional study is to test the feasibility of 12 weeks of aerobic exercise for people with advanced multiple sclerosis (i.e., wheelchair users). The main questions it aims to answer are:
- Is the exercise intervention feasible in terms of study processes, resources, management, safety, and acceptability?
- Can the intervention improve aerobic fitness, function in daily life, cognition, symptoms of fatigue and pain, and sensation?
- What are participants' experiences of taking part in the exercise intervention?
Participants will take part in moderate-intensity aerobic exercise twice a week for 12 weeks in a supervised research setting. Outcomes will be measured at baseline (0 weeks), mid-intervention (6 weeks), post-intervention (12 weeks), and 12-weeks after the intervention (24 weeks). The outcomes include feasibility measures, aerobic fitness, function in daily life, cognition, symptoms of fatigue and pain, sensation, and participant experiences of taking part in the exercise intervention.
Conditions: Multiple Sclerosis
Interventions: Aerobic Exercise Training
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