taVNS During Multi-site HRV Measurement: Reliability & Agreement Study
ClinicalTrials.gov Studies
Summary
This study evaluates the reliability and agreement of autonomic nervous system measurements collected from different anatomical sites—chest (reference), finger, and arm—during transcutaneous auricular vagus nerve stimulation (taVNS) in healthy volunteers aged 18–40 years. Data collection occurs across three standardized periods: T0 (5-minute resting baseline), T1 (10 minutes during taVNS), and T2 (5-minute recovery), with heart rate variability, blood pressure, and pulse recorded at each site. The primary objective is to determine how closely finger- and arm-based measurements match the chest reference and how consistent these measurements are across study periods. Participation is voluntary with minimal expected risks including temporary tingling or mild ear discomfort.
“The main goal is to determine how closely finger- and arm-based measurements match the chest reference and how consistent these measurements are across the study periods.”
Institutions and investigators designing multi-site HRV measurement protocols for taVNS research may find this trial's methodology informative for their own site-selection decisions and reference-standard calibration procedures.
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What changed
This ClinicalTrials.gov registration records a new observational study (NCT07548723) designed to assess measurement reliability for autonomic nervous system parameters during taVNS. The study protocol specifies data collection at three standardized time points using three anatomical measurement sites, with chest as the reference. Researchers studying taVNS or autonomic function should note that this trial focuses on measurement methodology rather than clinical efficacy endpoints.
For clinical investigators and research institutions conducting taVNS studies, this trial provides methodological reference points for site selection and measurement protocol design. The emphasis on inter-site agreement and within-period consistency addresses a practical validity question for multi-site HRV research protocols.
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Apr 24, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
taVNS During Multi-site HRV Measurement: Reliability & Agreement Study
N/A NCT07548723 Kind: NA Apr 23, 2026
Abstract
This study examines the reliability and agreement of autonomic nervous system measurements obtained from different anatomical sites during transcutaneous auricular vagus nerve stimulation (taVNS). taVNS is a non-invasive electrical stimulation delivered to the ear using a small stimulator. Healthy volunteers aged 18-40 years will participate in one laboratory session. Heart rate and heart rate variability will be recorded from the chest (reference), finger, and arm. Blood pressure and pulse will also be measured. Data will be collected in three standardized periods: T0 (5-minute resting baseline), T1 (10 minutes during taVNS), and T2 (5-minute recovery). The main goal is to determine how closely finger- and arm-based measurements match the chest reference and how consistent these measurements are across the study periods. Participation is voluntary, and participants may withdraw at any time. Expected risks are minimal and may include temporary tingling or mild discomfort at the ear and, rarely, lightheadedness. No direct medical benefit is expected, but the findings may help improve how autonomic responses are monitored during taVNS in future research.
Conditions: Autonomic Nervous System (ANS) Functioning and Mood State, Heart Rate Variability (HRV), Blood Pressure Monitoring, Transcutaneous Electric Nerve Stimulation, Photoplethysmography
Interventions: Transcutaneous auricular vagus nerve stimulation
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