SMARCA2/4 Degrader Compounds and Compositions Patent
Summary
USPTO published patent application US20260092071A1 for compounds of Formula II as SMARCA2 or SMARCA4 degraders, including their pharmaceutical compositions and uses. The application (No. 19112750) was filed on September 22, 2023, with 14 inventors including Shaomeng Wang and colleagues. This is a publication of a patent application in the field of heterocyclic compounds for potential therapeutic use.
What changed
USPTO published patent application US20260092071A1 covering compounds of Formula II and their pharmaceutical acceptable salts, solvates, or stereoisomers as SMARCA2 or SMARCA4 degraders. The application includes claims for compositions and methods of use. CPC classifications indicate applications in heterocyclic compounds (C07D 487/10, C07D 487/04), pharmaceutical preparations (A61K 31/519, A61K 31/527), with filing date September 22, 2023 under Application No. 19112750.\n\nThis is an informational publication of a patent application; no compliance actions, deadlines, or penalties apply. Companies developing targeted protein degradation therapies or SMARCA2/4 inhibitors should monitor this application for potential freedom-to-operate considerations. The published application provides public notice but does not yet grant patent rights.
Archived snapshot
Apr 2, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
COMPOUNDS AND COMPOSITIONS AS SMARCA2/4 DEGRADERS AND USES THEREOF
Application US20260092071A1 Kind: A1 Apr 02, 2026
Inventors
Shaomeng Wang, Lingying Leng, Lin Yang, Wenbin Tu, Liyue Huang, Mi Wang, Wei Jiang, Paul Kirchhoff, Guozhang Xu, Zhenwu Li, Lalgudi Harikrishnan, E. Scott Priestley, Jelena Tosovic, Jeanne Stuckey
Abstract
Described herein are compounds of Formula II and their pharmaceutically acceptable salts, solvates, or stereoisomers, as well as their uses (e.g., as SMARCA2 or SMARCA4 degraders).
CPC Classifications
C07D 487/10 A61K 31/519 A61K 31/527 A61K 31/5377 A61K 31/541 C07D 471/20 C07D 487/04 C07D 487/20 C07D 491/20 C07D 519/00
Filing Date
2023-09-22
Application No.
19112750
Named provisions
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