Changeflow GovPing Healthcare & Life Sciences USPTO Patent Grant: RAS Oncoprotein Inhibitors
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USPTO Patent Grant: RAS Oncoprotein Inhibitors

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Summary

The USPTO has granted patent US12582660B2 to the University of Louisville Research Foundation, Inc. for inhibitors of the RAS oncoprotein, methods of making, and methods of use thereof. The patent covers compounds useful in treating diseases associated with activating mutations in RAS, particularly cancer.

Published by USPTO on changeflow.com . Detected, standardized, and enriched by GovPing. Review our methodology and editorial standards .

What changed

The United States Patent and Trademark Office (USPTO) has issued patent US12582660B2, covering compounds for treating diseases associated with RAS oncoprotein activity, including cancer. The patent, assigned to the University of Louisville Research Foundation, Inc., details specific compounds of Formula (I) and their therapeutic applications.

This patent grant signifies a new intellectual property right for the assignee. While not a regulatory mandate for other entities, it establishes exclusive rights for the patent holder in the US for the claimed inventions. Companies involved in oncology drug development, particularly those targeting RAS pathways, should be aware of this granted patent to avoid potential infringement and to understand the competitive landscape.

Archived snapshot

Mar 24, 2026

GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.

← USPTO Patent Grants

Inhibitors of the RAS oncoprotein, methods of making and methods of use thereof

Grant US12582660B2 Kind: B2 Mar 24, 2026

Assignee

University of Louisville Research Foundation, Inc.

Inventors

Geoffrey J. Clark, John O. Trent, Joseph A. Burlison

Abstract

A compound for use in treating a disease associated with activating mutations in RAS, or for use in treating a disease treatable by a reduction in RAS activity, is selected from a compound of Formula (I), salts and esters thereof. The compounds are particularly useful in treating cancer.

CPC Classifications

C07K 16/2818 A61K 31/55 A61K 31/40 A61K 31/357

Filing Date

2019-05-10

Application No.

17053057

Claims

20

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Named provisions

Inhibitors of the RAS oncoprotein, methods of making and methods of use thereof

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Last updated

Classification

Agency
USPTO
Published
March 24th, 2026
Instrument
Rule
Legal weight
Non-binding
Stage
Final
Change scope
Minor
Document ID
US12582660B2

Who this affects

Applies to
Drug manufacturers Pharmaceutical companies
Industry sector
3254 Pharmaceutical Manufacturing
Activity scope
Drug Development Cancer Treatment
Geographic scope
United States US

Taxonomy

Primary area
Pharmaceuticals
Operational domain
Legal
Topics
Drug Development Cancer Treatment

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