Inhibitors of the RAS oncoprotein, methods of making and methods of use thereof
Grant
US12582660B2
Kind: B2
Mar 24, 2026
Assignee
University of Louisville Research Foundation, Inc.
Inventors
Geoffrey J. Clark, John O. Trent, Joseph A. Burlison
Abstract
A compound for use in treating a disease associated with activating mutations in RAS, or for use in treating a disease treatable by a reduction in RAS activity, is selected from a compound of Formula (I), salts and esters thereof. The compounds are particularly useful in treating cancer.
CPC Classifications
C07K 16/2818
A61K 31/55
A61K 31/40
A61K 31/357
Filing Date
2019-05-10
Application No.
17053057
Claims
20