Verification of Range Accuracy and Correlation With Clinical Toxicity Using Offline PET/CT for Hypofractionated Proton Radiotherapy in Breast Cancer

A newly registered clinical trial NCT07543107 has been posted on ClinicalTrials.gov. The study is a single-arm, single-center prospective observational trial using offline PET/CT to verify and quantify range accuracy of hypofractionated proton radiotherapy for postoperative breast cancer. The trial will analyze correlation between range error and clinical toxicities (radiation pneumonitis, rib fracture) and establish a PET signal-proton range correlation model using Monte Carlo simulation.

Breast cancer patients being considered for proton therapy at the participating center may be eligible for enrollment. Clinical researchers and radiotherapy treatment planners may follow the study's findings regarding range verification and toxicity correlation to inform proton therapy optimization strategies.