ORHEELS Randomized Radiotherapy Trial for Heel Spur Syndrome
Summary
The ORHEELS trial (NCT07546240) registered on ClinicalTrials.gov on April 22, 2026, will compare two low-dose radiotherapy fractionation schedules for Heel Spur Syndrome. The study plans to enroll patients with HSS who have failed conservative care, randomizing them to either a Polish standard dose of 6 Gy in 6 daily fractions (5x/week) or a reduced dose of 3 Gy delivered twice weekly. The trial's primary objective is to assess non-inferiority between daily and twice-weekly radiation fractionation regimens, with approximately 30% of HSS patients estimated to have persistent pain despite conservative treatment.
“Low-dose radiation therapy (LDRT) is a well-established European method with proven anti-inflammatory and immunomodulatory effects.”
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What changed
The ORHEELS randomized clinical trial registration describes a comparative effectiveness study evaluating two low-dose radiotherapy fractionation protocols for Heel Spur Syndrome, a condition affecting approximately 10% of adults with roughly 30% experiencing persistent pain despite conservative treatment. The trial compares a Polish standard protocol (6 Gy total, 1 Gy per fraction, 5 times/week) against an alternative reduced-dose schedule (3 Gy total, 0.5 Gy per fraction, twice weekly).
For clinical investigators and healthcare providers, this trial registration signals ongoing interest in low-dose radiation therapy as an alternative for refractory musculoskeletal conditions. Patients with chronic heel pain who have exhausted conservative options may be candidates for enrollment. The study is registered with NIH via ClinicalTrials.gov, indicating federal oversight of research integrity standards.
Archived snapshot
Apr 22, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Optimal Radiotherapy - Heel Spur Syndrome - Randomized Clinical Trial
N/A NCT07546240 Kind: NA Apr 22, 2026
Abstract
Heel Spur Syndrome (HSS), is a pathology characterized by chronic inflammation and degenerative changes that affect approximately 10% of adults. Although many patients respond to conservative care, about 30% experience persistent pain. Low-dose radiation therapy (LDRT) is a well-established European method with proven anti-inflammatory and immunomodulatory effects. The ORHEELS trial aims to assess whether a Polish standard dose of 6 Gy in 6 daily fractions (fx)(5 times/week) is not inferior to the treatment with total dose of 3 Gy / fx 0,5 Gy /fractionated twice weekly. The study is designed to assess the impact of intensity of treatment (daily (5 times / week) versus twice weekly fractionation) on clinical outcomes.
Conditions: Heel Spur Syndrome
Interventions: Standard fractioned dose, Reduced fractioned dose, Reduced fractioned dose & Intensity
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