Peak Airway Pressure and Respiratory Mechanics During PRVC Ventilation in Laparoscopic Surgery
Summary
NIH has registered an observational clinical trial (NCT07543939) titled 'Peak Airway Pressure and Respiratory Mechanics During PRVC Ventilation in Laparoscopic Surgery,' last updated on April 22, 2026. The study will evaluate peak airway pressure, dynamic compliance, and other ventilatory parameters across different intraoperative phases in patients undergoing elective laparoscopic abdominal surgery under pneumoperitoneum. Findings are intended to guide ventilatory strategy optimization and reduce ventilator-associated complications in this surgical population.
“The study will assess changes in peak airway pressure, dynamic compliance, and other ventilatory parameters during different intraoperative phases.”
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What changed
The NIH has registered a new observational clinical trial (NCT07543939) on ClinicalTrials.gov evaluating peak airway pressure and respiratory mechanics during pressure-regulated volume control (PRVC) ventilation in patients undergoing elective laparoscopic abdominal surgery. The study will assess changes in peak airway pressure, dynamic compliance, and other ventilatory parameters during pneumoperitoneum and different intraoperative positioning phases. This is a protocol registration only; no enrollment status, results, or compliance obligations are established by this filing.
For healthcare providers and clinical investigators, this registration signals an upcoming evidence source on intraoperative ventilatory management during laparoscopy. Anesthesiologists and surgical teams using PRVC ventilation may wish to track enrollment and outcomes for future practice guidance once results are published.
Archived snapshot
Apr 22, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Peak Airway Pressure and Respiratory Mechanics During PRVC Ventilation in Laparoscopic Surgery
Observational NCT07543939 Kind: OBSERVATIONAL Apr 22, 2026
Abstract
This study aims to evaluate peak airway pressure and respiratory mechanics during pressure-regulated volume control (PRVC) ventilation in patients undergoing elective laparoscopic abdominal surgery. Pneumoperitoneum and patient positioning during laparoscopic procedures can significantly affect respiratory mechanics, including airway pressures and lung compliance.
The study will assess changes in peak airway pressure, dynamic compliance, and other ventilatory parameters during different intraoperative phases. The findings are expected to provide insights into optimizing ventilatory strategies to improve patient safety and minimize ventilator-associated complications during laparoscopic surgery.
Conditions: Intraoperative Ventilation, Respiratory Mechanics
Interventions: PRVC Ventilation
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