Polyamine Reporters - Pushkal Sharma, Ankur Jain
Summary
The USPTO published patent application US20260109740A1 by inventors Pushkal Sharma and Ankur Jain on April 23, 2026. The application discloses polynucleotides comprising a polyamine-responsive element and a reporter protein coding sequence, where interaction between a polyamine and the polyamine-responsive element modulates expression of the reporter protein. The invention enables methods of reporting and detecting intracellular polyamines and polyamine analogs.
“interaction between a polyamine and the polyamine-responsive element modulates expression of the reporter protein”
About this source
USPTO classification C07K covers peptides: short amino-acid chains that form the backbone of antibodies, hormones, vaccines, and increasingly a wider class of therapeutic modalities. Every newly published application in C07K lands in this feed, around 175 a month. Applications publish 18 months after filing, so this feed reveals what antibody engineering groups, vaccine developers, and plant biotech researchers were working on in the prior year and a half. Watch this if you compete in biologics, file freedom-to-operate analyses on antibody drug candidates, scout acquisition targets in vaccine platforms, or track protein-based agricultural biotech filings.
What changed
The USPTO published Application US20260109740A1, a patent application disclosing polynucleotides comprising a polyamine-responsive element and a reporter protein coding sequence for detecting intracellular polyamines and polyamine analogs.
Affected parties include biotechnology and pharmaceutical companies engaged in polyamine-targeted therapeutic development or diagnostic assay design. Patent professionals should monitor this application's prosecution for freedom-to-operate considerations.
Archived snapshot
Apr 23, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Polyamine Reporters
Application US20260109740A1 Kind: A1 Apr 23, 2026
Inventors
Pushkal Sharma, Ankur Jain
Abstract
The disclosure provides, in various embodiments, polynucleotides comprising a polyamine-responsive element and a reporter protein coding sequence encoding a reporter protein, wherein interaction between a polyamine and the polyamine-responsive element modulates expression of the reporter protein. The disclosure also provides, in various embodiments, vectors cells, and kits comprising the polynucleotides, methods of reporting an intracellular polyamine, and methods of detecting and/or reporting an intracellular polyamine analog.
CPC Classifications
C07K 14/47 C12N 15/625 C12N 15/63 G01N 33/68 C07K 2319/09 C07K 2319/60 C07K 2319/95
Filing Date
2025-08-22
Application No.
19307589
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