Pleural Effusion Types in Chronic Kidney Disease Observational Study
Summary
This ClinicalTrials.gov registry entry documents an observational study (NCT07547852) enrolling adult patients with advanced Chronic Kidney Disease (CKD Stages 3-5) who have confirmed pleural effusion. Researchers will perform ultrasound-guided diagnostic thoracentesis to compare chest fluid against blood samples using standard Light's Criteria, abbreviated criteria, and the Serum-Pleural Effusion Albumin Gradient (SPAG) to better classify fluid types in kidney disease patients whose baseline protein levels may alter standard test accuracy.
“Researchers in this study will enroll adult CKD patients (both on dialysis and not yet on dialysis) who have confirmed fluid around their lungs.”
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What changed
This ClinicalTrials.gov registry entry describes an observational study examining pleural effusion classification accuracy in chronic kidney disease patients. The study will enroll adult CKD patients (dialysis and non-dialysis) and compare standard chest fluid classification methods against alternative criteria including SPAG to address known limitations of Light's Criteria in this population.
Affected parties — clinical investigators, pulmonologists, and nephrologists — may encounter updated references to this study when evaluating pleural effusion in CKD patients. The registry entry itself does not impose compliance obligations but provides a reference point for clinical decision-making in kidney disease management.
Archived snapshot
Apr 23, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Pleural Effusion Types in Chronic Kidney Disease
Observational NCT07547852 Kind: OBSERVATIONAL Apr 23, 2026
Abstract
The purpose of this observational study is to understand the causes of pleural effusion (a buildup of fluid around the lungs) in patients with advanced Chronic Kidney Disease (CKD Stages 3 to 5). Pleural effusion is a common complication in kidney disease, but it can be caused by many different issues, such as simple fluid overload, heart failure, or infections like tuberculosis.
To treat this fluid buildup effectively, doctors need to classify whether the fluid is a transudate (usually caused by pressure imbalances like fluid overload) or an exudate (caused by inflammation, lung disease, or infection). Standard medical formulas, known as Light's Criteria, are typically used to figure this out by comparing proteins in the fluid to proteins in the blood. However, these standard tests may sometimes misclassify the fluid in kidney disease patients because their baseline blood protein and albumin levels are often altered by their condition.
Researchers in this study will enroll adult CKD patients (both on dialysis and not yet on dialysis) who have confirmed fluid around their lungs. Participants will undergo a standard, ultrasound-guided procedure called a diagnostic thoracentesis to safely draw a small amount of the chest fluid. At the same time, a routine blood sample will be taken.
The study aims to:
- Compare the chest fluid to the blood sample using standard criteria, abbreviated criteria, and the Serum-Pleural Effusion Albumin Gradient (SPAG).
- Determine the most co...
Conditions: Pleural Effusion, Chronic Kidney Disease
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