Surfactant Administration Methods in Preterm Infants With RDS: A Swedish Cohort Study
Summary
NIH registered an observational cohort study (NCT07550218) titled 'Surfactant Administration Methods in Preterm Infants With RDS: A Swedish Cohort Study' on April 24, 2026. The study will prospectively collect clinical data on preterm infants with respiratory distress syndrome receiving surfactant via various methods (INSURE, LISA, SALSA, or traditional intubation), using long-term follow-up data from the Swedish Neonatal Quality Register. Results are intended to inform the design of a future randomized multicenter study.
“The study will prospectively collect clinical data on infants receiving surfactant as part of standard care, with long-term follow-up using data from the Swedish Neonatal Quality Register.”
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What changed
This entry records the registration of an observational cohort study evaluating surfactant administration methods in preterm infants with respiratory distress syndrome. The study is conducted in Sweden and will collect data from the Swedish Neonatal Quality Register. No regulatory obligations are created by this registration — it is an informational record of planned research.
Healthcare providers and clinical investigators involved in neonatal care may find this study relevant to ongoing debates about optimal surfactant delivery techniques. The study compares four methods: INSURE (brief intubation), LISA (thin catheter), SALSA (laryngeal mask), and traditional endotracheal intubation with mechanical ventilation.
Archived snapshot
Apr 25, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Surfactant Administration Methods in Preterm Infants With RDS: A Swedish Cohort Study
Observational NCT07550218 Kind: OBSERVATIONAL Apr 24, 2026
Abstract
The goal of this observational study is to evaluate different methods of surfactant administration in preterm infants with respiratory distress syndrome (RDS). Preterm infants often have immature lungs and a deficiency of surfactant, a substance that helps keep the lungs open and supports oxygen exchange.Surfactant can be delivered to the lungs using different techniques, including INSURE (brief intubation), LISA (via a thin catheter), SALSA (via a laryngeal mask airway), and traditional administration via endotracheal intubation followed by mechanical ventilation. The main question this study aims to answer is:Which method of surfactant administration is associated with better clinical outcomes in preterm infants with RDS?The study will prospectively collect clinical data on infants receiving surfactant as part of standard care, with long-term follow-up using data from the Swedish Neonatal Quality Register. The results are intended to be used to inform the design of a future randomized multicenter study.
Conditions: Respiratory Distress Syndrome (& [Hyaline Membrane Disease]), Respiratory Distress Syndrome (Neonatal), Respiratory Distress Syndrome (RDS), Respiratory Distress Syndrome of Newborn, Respiratory Distress Syndrome in Premature Infant
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