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MInimizing Delirium With Nasal Dexmedetomidine-InducEd Sleep (MIDDIES)

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Summary

NIH registered a Phase 2 clinical trial (NCT07538284) titled MIDDIES on ClinicalTrials.gov. The trial will study whether nighttime self-administration of nasal dexmedetomidine is effective at inducing sleep and preventing postoperative delirium in high-risk patients undergoing major abdominal surgery, compared with placebo.

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What changed

The trial registration documents a new Phase 2 interventional study on ClinicalTrials.gov evaluating intranasal dexmedetomidine as a potential treatment for preventing postoperative delirium in surgical patients. The study will enroll participants receiving either dexmedetomidine or placebo as nighttime interventions. This is an informational registry entry without direct compliance obligations.

Healthcare providers and clinical investigators should note this trial if involved in perioperative care or delirium research. Patients scheduled for major abdominal surgery at participating sites may be eligible for enrollment consideration.

Archived snapshot

Apr 20, 2026

GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.

← ClinicalTrials.gov Studies

MInimizing Delirium With Nasal Dexmedetomidine-InducEd Sleep (MIDDIES)

Phase 2 NCT07538284 Kind: PHASE2 Apr 20, 2026

Abstract

This study aims to determine whether, compared with placebo, the nighttime self-administration of a nasal dexmedetomidine is effective at inducing sleep and preventing postoperative delirium in high-risk patients.

Conditions: Major Abdominal Surgery, Postoperative Delirium (POD), Sleep Disturbances, Intranasal Dexmedetomidine

Interventions: Dexmedetomidine, Placebo

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Last updated

Classification

Agency
NIH
Instrument
Notice
Branch
Executive
Legal weight
Non-binding
Stage
Final
Change scope
Minor

Who this affects

Applies to
Healthcare providers Clinical investigators Pharmaceutical companies
Industry sector
3254 Pharmaceutical Manufacturing
Activity scope
Clinical trial participation Perioperative delirium prevention Sleep disturbance treatment
Geographic scope
United States US

Taxonomy

Primary area
Pharmaceuticals
Operational domain
Clinical Operations
Topics
Healthcare Medical Devices

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