MInimizing Delirium With Nasal Dexmedetomidine-InducEd Sleep (MIDDIES)
Summary
NIH registered a Phase 2 clinical trial (NCT07538284) titled MIDDIES on ClinicalTrials.gov. The trial will study whether nighttime self-administration of nasal dexmedetomidine is effective at inducing sleep and preventing postoperative delirium in high-risk patients undergoing major abdominal surgery, compared with placebo.
What changed
The trial registration documents a new Phase 2 interventional study on ClinicalTrials.gov evaluating intranasal dexmedetomidine as a potential treatment for preventing postoperative delirium in surgical patients. The study will enroll participants receiving either dexmedetomidine or placebo as nighttime interventions. This is an informational registry entry without direct compliance obligations.
Healthcare providers and clinical investigators should note this trial if involved in perioperative care or delirium research. Patients scheduled for major abdominal surgery at participating sites may be eligible for enrollment consideration.
Archived snapshot
Apr 20, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
MInimizing Delirium With Nasal Dexmedetomidine-InducEd Sleep (MIDDIES)
Phase 2 NCT07538284 Kind: PHASE2 Apr 20, 2026
Abstract
This study aims to determine whether, compared with placebo, the nighttime self-administration of a nasal dexmedetomidine is effective at inducing sleep and preventing postoperative delirium in high-risk patients.
Conditions: Major Abdominal Surgery, Postoperative Delirium (POD), Sleep Disturbances, Intranasal Dexmedetomidine
Interventions: Dexmedetomidine, Placebo
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