Changeflow GovPing Healthcare & Life Sciences Phase 2 Trial, Mosunetuzumab Plus Pirtobrutinib...
Routine Notice Added Final

Phase 2 Trial, Mosunetuzumab Plus Pirtobrutinib, Waldenstrom Macroglobulinemia

Favicon for changeflow.com ClinicalTrials.gov Studies
Published
Detected
Email

Summary

NIH ClinicalTrials.gov has registered a Phase 2 clinical trial (NCT07548450) to evaluate the safety and tolerability of mosunetuzumab in combination with pirtobrutinib in patients with relapsed or refractory Waldenstrom Macroglobulinemia. The trial, designated MPOWER, involves two interventions and is classified as Phase 2. Healthcare providers and clinical investigators involved in hematologic oncology research may consider this trial relevant for patient referral or study participation.

“The purpose of this clinical trial it to test the safety and tolerability of the study drugs mosunetuzumab in combination with pirtobrutinib in patients with relapsed or refractory Waldenstrom's Macroglobulinemia.”

NIH , verbatim from source
Published by NIH on changeflow.com . Detected, standardized, and enriched by GovPing. Review our methodology and editorial standards .

About this source

ClinicalTrials.gov is the NIH-run registry of every clinical trial conducted in the United States, plus most international trials sponsored by US-based companies or institutions. By federal law, sponsors must register Phase 2 through Phase 4 studies before enrolling patients and post results within a year of completion. This feed tracks every new trial registration and study update, around 700 a month: drug interventions, device studies, behavioral protocols, observational research. Watch this if you scout drug candidates moving into mid or late-stage development, monitor competitor pipelines, or follow rare disease research where new trials signal patient hope. GovPing parses sponsor, phase, intervention, and target indication on each entry.

What changed

NIH ClinicalTrials.gov has registered a Phase 2 clinical trial (NCT07548450) designated as MPOWER, evaluating mosunetuzumab in combination with pirtobrutinib for the treatment of relapsed or refractory Waldenstrom Macroglobulinemia. The trial will assess safety and tolerability of this drug combination in patients with this rare B-cell lymphoproliferative disorder. Pharmaceutical companies with research programs in hematologic oncology and clinical investigators specializing in Waldenstrom Macroglobulinemia should be aware of this trial registration as it represents an additional competitive development pathway for both agents.

Archived snapshot

Apr 23, 2026

GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.

← ClinicalTrials.gov Studies

Mosunetuzumab in Combination With Pirtobrutinib in Patients With Relapsed or Refractory Waldenstrom Macroglobulinemia (MPOWER)

Phase 2 NCT07548450 Kind: PHASE2 Apr 23, 2026

Abstract

The purpose of this clinical trial it to test the safety and tolerability of the study drugs mosunetuzumab in combination with pirtobrutinib in patients with relapsed or refractory Waldenstrom's Macroglobulinemia.

Conditions: Waldenstrom Macroglobulinemia

Interventions: Pirtobrutinib, Mosunetuzumab

View original document →

Get daily alerts for ClinicalTrials.gov Studies

Daily digest delivered to your inbox.

Free. Unsubscribe anytime.

About this page

What is GovPing?

Every important government, regulator, and court update from around the world. One place. Real-time. Free. Our mission

What's from the agency?

Source document text, dates, docket IDs, and authority are extracted directly from NIH.

What's AI-generated?

The summary, classification, recommended actions, deadlines, and penalty information are AI-generated from the original text and may contain errors. Always verify against the source document.

Last updated

Classification

Agency
NIH
Published
April 23rd, 2026
Instrument
Notice
Branch
Executive
Legal weight
Non-binding
Stage
Final
Change scope
Minor
Document ID
NCT07548450

Who this affects

Applies to
Pharmaceutical companies Clinical investigators
Industry sector
3254 Pharmaceutical Manufacturing
Activity scope
Clinical trial participation
Geographic scope
United States US

Taxonomy

Primary area
Pharmaceuticals
Operational domain
Clinical Operations
Topics
Healthcare

Get alerts for this source

We'll email you when ClinicalTrials.gov Studies publishes new changes.

Free. Unsubscribe anytime.

You're subscribed!