Phase 2 Trial, Mosunetuzumab Plus Pirtobrutinib, Waldenstrom Macroglobulinemia
Summary
NIH ClinicalTrials.gov has registered a Phase 2 clinical trial (NCT07548450) to evaluate the safety and tolerability of mosunetuzumab in combination with pirtobrutinib in patients with relapsed or refractory Waldenstrom Macroglobulinemia. The trial, designated MPOWER, involves two interventions and is classified as Phase 2. Healthcare providers and clinical investigators involved in hematologic oncology research may consider this trial relevant for patient referral or study participation.
“The purpose of this clinical trial it to test the safety and tolerability of the study drugs mosunetuzumab in combination with pirtobrutinib in patients with relapsed or refractory Waldenstrom's Macroglobulinemia.”
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What changed
NIH ClinicalTrials.gov has registered a Phase 2 clinical trial (NCT07548450) designated as MPOWER, evaluating mosunetuzumab in combination with pirtobrutinib for the treatment of relapsed or refractory Waldenstrom Macroglobulinemia. The trial will assess safety and tolerability of this drug combination in patients with this rare B-cell lymphoproliferative disorder. Pharmaceutical companies with research programs in hematologic oncology and clinical investigators specializing in Waldenstrom Macroglobulinemia should be aware of this trial registration as it represents an additional competitive development pathway for both agents.
Archived snapshot
Apr 23, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Mosunetuzumab in Combination With Pirtobrutinib in Patients With Relapsed or Refractory Waldenstrom Macroglobulinemia (MPOWER)
Phase 2 NCT07548450 Kind: PHASE2 Apr 23, 2026
Abstract
The purpose of this clinical trial it to test the safety and tolerability of the study drugs mosunetuzumab in combination with pirtobrutinib in patients with relapsed or refractory Waldenstrom's Macroglobulinemia.
Conditions: Waldenstrom Macroglobulinemia
Interventions: Pirtobrutinib, Mosunetuzumab
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