Changeflow GovPing Healthcare & Life Sciences Patent Grant for In Vivo Radiation Dosimetry Tool
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Patent Grant for In Vivo Radiation Dosimetry Tool

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Summary

The USPTO has granted a patent (US12582846B2) to The Regents of the University of California for an in vivo radiation dosimetry tool. This tool utilizes X-ray-induced acoustic computed tomography (XACT) to measure absolute radiation dose delivered during radiotherapy, aiming to improve precision and patient outcomes in cancer treatment.

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What changed

The United States Patent and Trademark Office (USPTO) has issued patent US12582846B2 for an "Absolute in vivo radiation dosimetry tool with XACT imaging." The patent, assigned to The Regents of the University of California, describes a system using X-ray-induced acoustic computed tomography (XACT) with a model-based reconstruction method to measure the absolute radiation dose delivered to tumors and surrounding tissues during radiotherapy. This technology aims to enhance the precision of cancer treatment by providing real-time, absolute dose information, potentially leading to more personalized treatment plans and improved patient outcomes.

This patent grant represents a new technological development in medical devices for radiation therapy. While not a regulatory rule imposing new compliance obligations, it signifies innovation in the field of oncology treatment monitoring. Healthcare providers and medical device manufacturers involved in radiotherapy should be aware of this patented technology, as it may influence future treatment protocols, device development, and clinical research. The patent details the use of thermal parameters and calibration tools like ion chambers for accurate dose reconstruction, highlighting potential areas for technological advancement and integration into clinical practice.

Archived snapshot

Mar 26, 2026

GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.

← USPTO Patent Grants

Absolute in vivo radiation dosimetry tool with XACT imaging

Grant US12582846B2 Kind: B2 Mar 24, 2026

Assignee

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventors

Liangzhong Xiang, Leshan Sun

Abstract

The present embodiments relate generally to increasing the precision of radiotherapy by measuring the absolute dose delivered to the tumor and surrounding normal tissue during the treatment. More particularly, some embodiments relate to an imaging reconstruction system for X-ray-induced acoustic computed tomography (XACT) using a model-based reconstruction method. Instead of reconstructing relative dose information for radiation beam localization, the system is capable of reconstructing absolute in vivo dose information. The XACT absolute in vivo dosimetry tool holds great potential for personalized cancer treatment and better outcomes. In some embodiments, thermal parameters, such as Gruneisen parameters, are used to convert reconstructed pressure information to dose. In addition, to avoid problems caused by electrical system gain, calibration tools, such as ion chambers, can be used to calibrate the system.

CPC Classifications

A61N 5/1071 A61B 5/0093 A61B 8/13 A61B 6/4258 A61B 6/5247 A61B 6/582

Filing Date

2022-11-07

Application No.

18708196

Claims

16

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Last updated

Classification

Agency
USPTO
Published
March 24th, 2026
Instrument
Notice
Legal weight
Non-binding
Stage
Final
Change scope
Minor
Document ID
US12582846B2

Who this affects

Applies to
Drug manufacturers Medical device makers Healthcare providers
Industry sector
3345 Medical Device Manufacturing 6211 Healthcare Providers
Activity scope
Radiotherapy Medical Device Development
Geographic scope
United States US

Taxonomy

Primary area
Healthcare
Operational domain
Research & Development
Topics
Medical Devices Pharmaceuticals

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