Compositions and Methods for Enzymatic Production of Polyphenol Aglycone Compounds
Summary
USPTO published patent application US20260110012A1 on April 23, 2026, covering glycoside hydrolase compositions and methods for enzymatic production of polyphenol aglycone compounds. The application (filed October 17, 2025, Application No. 19361768) names inventors Jose A. Amaya, Jeffrey Ehrhardt, Jingyi Li, and Drew Taylor Wagner, and includes CPC classifications C12P 19/46, C12N 9/2402, and C12P 19/14. Patent applications are published to inform the public and initiate the examination process; they do not yet confer enforceable patent rights.
“The present disclosure provides compositions comprising a glycoside hydrolase and one or both of hesperidin and hesperetin, wherein an active site of the glycoside hydrolase comprises first, second, third, fourth, and fifth regions as described herein.”
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GovPing monitors USPTO Patent Applications - Biotech (C12N) for new healthcare & life sciences regulatory changes. Every update since tracking began is archived, classified, and available as free RSS or email alerts — 264 changes logged to date.
What changed
USPTO published a patent application (US20260110012A1) for compositions and methods involving glycoside hydrolase enzymes in the production of polyphenol aglycone compounds, including hesperidin and hesperetin derivatives. The application discloses host cells, heterologous expression systems, and encoding nucleic acids. Patent applicants, competitors in biotechnology and pharmaceutical research, and companies developing polyphenol-based products should monitor this application for potential freedom-to-operate implications once the patent prosecution concludes.
Archived snapshot
Apr 24, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
COMPOSITIONS AND METHODS FOR ENZYMATIC PRODUCTION OF POLYPHENOL AGLYCONE COMPOUNDS
Application US20260110012A1 Kind: A1 Apr 23, 2026
Inventors
Jose A. AMAYA, Jeffrey EHRHARDT, Jingyi LI, Drew Taylor WAGNER
Abstract
The present disclosure provides compositions comprising a glycoside hydrolase and one or both of hesperidin and hesperetin, wherein an active site of the glycoside hydrolase comprises first, second, third, fourth, and fifth regions as described herein. The present disclosure also relates to methods for producing a polyphenol aglycone, comprising contacting a phenolic glycoside with a glycoside hydrolase described herein. Also provided are host cells and heterologous expression systems capable of expressing a heterologous glycoside hydrolase, and nucleic acids encoding the glycoside hydrolase.
CPC Classifications
C12P 19/46 C12N 9/2402 C12P 19/14
Filing Date
2025-10-17
Application No.
19361768
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