NCT07542340: Osteopathic Intervention Migraine Clinical Trial
Summary
The National Institutes of Health registered clinical trial NCT07542340, a randomized study evaluating the effect of osteopathic intervention on migraine. The trial will enroll participants experiencing migraine and assign them to receive either an osteopathic intervention protocol or placebo technique. The study investigates whether manual therapy techniques targeting the upper neck may reduce migraine pain intensity and frequency.
What changed
Clinical trial NCT07542340 was registered with ClinicalTrials.gov as a new clinical study. The trial will evaluate whether osteopathic techniques such as suboccipital inhibition and C2 manipulation can reduce migraine pain intensity and frequency by normalising mobility and reducing nociceptive stimulation in the upper neck region.
Healthcare providers and clinical investigators involved in pain management research may find this trial relevant as it examines manual therapy approaches for migraine. The study uses a placebo-controlled design to assess the specific effect of osteopathic intervention against a sham technique.
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Apr 21, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Effect of Osteopathic Intervention on Migraine
N/A NCT07542340 Kind: NA Apr 21, 2026
Abstract
Migraine is a common, disabling neurological condition characterized by severe, often unilateral pain accompanied by sensory symptoms like nausea and photophobia. Its pathophysiology involves activation of the trigeminovascular system, neuro-inflammation, and nervous system sensitisation.
Due to the convergence of trigeminal and cervical nerves in the upper neck (C2), manual therapy may influence migraine symptoms. Osteopathic techniques, such as suboccipital inhibition and C2 manipulation, aim to reduce pain intensity and frequency by normalising mobility and reducing nociceptive stimulation. While promising, further research is needed to validate these interventions through rigorous clinical trials.
Conditions: Migraine
Interventions: Osteopathic Intervention Protocol, Placebo technique
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