Oligonucleotide Synthesis Method, USPTO, 23rd Apr

USPTO published patent application US20260109968A1 disclosing a method for simultaneous synthesis of a plurality of oligonucleotide molecules using orthogonal synthesis techniques. The application was filed August 31, 2023, and names five inventors. CPC classifications span C12N 15/1065, C12N 15/1068, C40B 40/06, and C40B 50/14, covering nucleic acid chemistry and combinatorial library methods.

Pharmaceutical and biotechnology companies engaged in oligonucleotide-based drug development or DNA-encoded library research should monitor this application for potential freedom-to-operate implications. The disclosed orthogonal synthesis method, if commercialized, could offer efficiency gains in preparing multiple distinct oligonucleotides concurrently, which is relevant to companies developing oligonucleotide therapeutics or conducting high-throughput screening via DEL.