Observational Study of Lymphocyte Subpopulations in PGCG, 28 Patients
Summary
ClinicalTrials.gov registration NCT07551310 describes an observational study evaluating lymphocyte subpopulations in Peripheral Giant Cell Granuloma tissues versus adjacent healthy gingival tissues. The study enrolled 28 systemically healthy, non-smoking patients diagnosed with PGCG. Biopsy samples were collected during surgical excision and analyzed via immunohistochemistry for CD3, CD4, CD8, CD20, and CD79a markers.
“A total of 28 systemically healthy, non-smoking patients diagnosed with PGCG are included in this study.”
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What changed
This ClinicalTrials.gov study registration documents a prospective observational investigation of immune cell markers in Peripheral Giant Cell Granuloma (PGCG), a non-neoplastic inflammatory gingival lesion. The study enrolled 28 patients who underwent surgical excision, with matched samples of diseased and healthy tissue analyzed for five lymphocyte subpopulation markers.
For clinical research sites and oral pathology investigators, this study adds to the evidence base on the immunological characteristics of PGCG. The methodological approach—using immunohistochemistry to compare diseased and healthy tissue from the same patients—may inform future study design for similar gingival lesion research.
Archived snapshot
Apr 24, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Lymphocyte Subpopulations in Peripheral Giant Cell Granuloma
Observational NCT07551310 Kind: OBSERVATIONAL Apr 24, 2026
Abstract
Peripheral giant cell granuloma (PGCG) is a non-neoplastic inflammatory lesion of gingival tissues. This study aims to evaluate and compare lymphocyte subpopulations in PGCG tissues and adjacent healthy gingival tissues obtained from the same individuals.
A total of 28 systemically healthy, non-smoking patients diagnosed with PGCG are included in this study. Biopsy samples are collected during surgical excision of PGCG lesions, and corresponding healthy gingival tissues are obtained from the same patients.
Immunohistochemical analysis is performed to assess lymphocyte subpopulations, including CD3, CD4, CD8, CD20, and CD79a. The proportions of these cells are compared between diseased and healthy tissues.
Conditions: Peripheral Giant Cell Granuloma, Gingival Lesions, Gingival Enlargement
Interventions: Immunohistochemical Analysis
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