Effect of Diode Laser, Gudmar and Vinegar in Diabetic Patients During Root Canal Treatment
Summary
NIH's ClinicalTrials.gov has registered NCT07549373, a prospective single-center study at Sharda University enrolling 60 Type 2 diabetic patients requiring root canal treatment, with a one-year convenience sampling period. Patients are divided into five groups of 15 each receiving different irrigation protocols: saline control, 5% apple cider vinegar, diode laser (940 nm) with saline, Gymnema Sylvestre mother tincture, or combined diode laser with either vinegar or Gymnema Sylvestre. Clinical outcomes will be assessed via periapical radiograph and pain measured by visual analog scale at 7, 15, 30, 45, and 60-day follow-up intervals.
“Patient with diabetes 2 with informed consent -convenience sampling over a one year period.”
About this source
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What changed
The ClinicalTrials.gov entry documents a randomized, controlled trial comparing five endodontic irrigation and disinfection protocols in diabetic patients: saline control, 5% apple cider vinegar, 940 nm diode laser, Gymnema Sylvestre mother tincture, and two combination arms. All patients undergo standardized root canal treatment with rubber dam isolation, ISO size 20 file instrumentation, and ZOE sealer/gutta percha obturation. Samples will be analyzed by traditional PCR for Peptostreptococcus spp. at the School of Basic Life Sciences, Sharda University.
Dental researchers and endodontists should note this trial's use of herbal and natural-product interventions (Gymnema sylvestre, apple cider vinegar) as alternatives to conventional chemical irrigants. Any institution planning similar integrative endodontic research should ensure Investigational Review Board approval and appropriate informed consent documentation for the diabetic patient population. The PCR-based microbiological endpoint provides a template for similarly rigorous outcome measurement in herbal-disinfection studies.
Archived snapshot
Apr 25, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Effect of Diode Laser, Gudmar and Vinegar in Diabetic Patients During Root Canal Treatment
N/A NCT07549373 Kind: NA Apr 24, 2026
Abstract
Methodology
Patient with diabetes 2 with informed consent -convenience sampling over a one year period.The tooth isolated with a rubber dam and the correct disinfection procedures will be used. researcher will do the Access preparation Working length -electronic apex locator (Dentsply Propex II) as well as a radiographic approach.
After the canals will be obturated using ZOE sealer and gutta percha and post endodontic restoration is done using composite restoration. Patient is kept on follow up for 7days, 15 days, 30 days ,45 days and 60 days Clinical outcome is measure using periapical radiograph (RVG) Pain is measured using visual analog scale to mark the pain intensity. Data will be analysed statistically To enlarge the root canals (ISO size 20 file)
A sterile paper point inside the root canal for one minute until the apex of the root canal is reached
Using T.E Buffer, samples will be delivered to the School Of Basic Life Sciences, Sharda University.
The samples will be subjected to traditional PCR analysis for the detection of Peptostreptococcus spp. in the root canal.
Grouping Following instrumentation, 5% NaOCl and 17% EDTA irrigation will be done. Control group (n=15) The final irrigant will be saline Group 1 (n=15) Irrigation using 5% apple cider vinegar done The final irrigant will be saline Group 2 (n=15) Diode laser is used for disinfection in the presence of saline Group 3 (n=15) Gymnema Sylvestre Mother Tincture Q 1000 CH solution is used for disinfectio...
Conditions: Diabete Type 2
Interventions: 940 nm diode laser, apple cider vinegar, Gymnema Sylvestre, Saline (NaCl), Diode laser and Gymnema Sylvestre, Diode laser and apple cider vinegar
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