Effect of Spinal and General Anesthesia on Frontal QRS Axis in Total Knee Arthroplasty
ClinicalTrials.gov Studies
Summary
NIH registered study NCT07551648, a prospective observational trial comparing frontal QRS axis changes in patients undergoing total knee arthroplasty under spinal versus general anesthesia. The study will enroll adults aged 18 years and older with ASA physical status I to III, using standard 12-lead electrocardiography to measure preoperative-to-postoperative QRS axis changes. Enrollment criteria, methodology, and outcome measures are now publicly available on ClinicalTrials.gov for research transparency purposes.
“This prospective observational study aims to compare the effects of spinal and general anesthesia on frontal QRS axis in patients undergoing elective total knee arthroplasty.”
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What changed
This ClinicalTrials.gov registration records a new prospective observational study comparing the cardiac electrical effects of spinal and general anesthesia in total knee arthroplasty patients. The study will measure frontal QRS axis changes using automatic 12-lead ECG device readings taken pre- and postoperatively.
Healthcare providers involved in orthopedic anesthesia care may find this registry entry useful for identifying relevant ongoing research in anesthesia cardiac effects. Patients and clinical investigators should note the enrollment criteria (ASA I-III status, elective TKA) when considering study participation or comparable institutional protocols.
Archived snapshot
Apr 28, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Effect of Spinal and General Anesthesia on Frontal QRS Axis in Patients Undergoing Total Knee Arthroplasty
Observational NCT07551648 Kind: OBSERVATIONAL Apr 27, 2026
Abstract
This prospective observational study aims to compare the effects of spinal and general anesthesia on frontal QRS axis in patients undergoing elective total knee arthroplasty. Adult patients aged 18 years and older with ASA physical status I to III will be included. Participants will be grouped according to the anesthesia technique applied in routine clinical practice. Standard 12-lead electrocardiography will be obtained preoperatively and postoperatively, and frontal QRS axis values will be recorded using the automatic measurements of the ECG device. The primary objective is to evaluate the preoperative-to-postoperative change in frontal QRS axis and to compare this change between patients receiving spinal anesthesia and those receiving general anesthesia. Demographic and perioperative variables, including comorbidities, intraoperative fluid administration, blood pressure, oxygen saturation, heart rate, and tourniquet time, will also be recorded. This study is designed to provide clinical information about the potential effects of anesthesia technique on cardiac electrical activity in patients undergoing total knee arthroplasty.
Conditions: Total Knee Arthroplasty, Electrocardiographic Changes
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