Effect of Non-pharmacological Intervention on Endothelial Function, Body Composition, and Physical Functionality in Recovered COVID-19 Patients
Summary
The NIH registered clinical trial NCT07544186, a randomized controlled study evaluating the effect of nutritional therapy combined with L-citrulline supplementation and pulmonary rehabilitation on endothelial function, body composition, and physical capacity in recovered COVID-19 patients. The intervention group receives 4g daily L-citrulline for 3 months plus pulmonary rehabilitation, compared against a control group receiving conventional treatment and pulmonary rehabilitation alone. The study includes an interim review session at 1.5 months and requires subjects to maintain supplement intake records.
“This study aims to evaluate the impact of a non-pharmacological treatment (nutritional therapy and pulmonary rehabilitation) on endothelial function, body composition, and physical functionality in recovered COVID-19 patients.”
About this source
GovPing monitors ClinicalTrials.gov Studies for new healthcare & life sciences regulatory changes. Every update since tracking began is archived, classified, and available as free RSS or email alerts — 667 changes logged to date.
What changed
This document registers a new clinical trial on ClinicalTrials.gov, describing a randomized controlled study examining the impact of non-pharmacological interventions on recovered COVID-19 patients. The study assigns subjects to receive either nutritional therapy with L-citrulline supplementation or conventional medical management, with both groups undergoing pulmonary rehabilitation. Key parameters include a 4g daily L-citrulline dosage, a 3-month treatment duration, and an interim review at 1.5 months.
Healthcare providers and clinical investigators involved in post-COVID care or rehabilitation research may find this trial relevant for understanding emerging non-pharmacological treatment approaches. The study's focus on endothelial function, body composition, and physical functionality addresses common post-acute sequelae of COVID-19.
Archived snapshot
Apr 22, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Effect of a Non-pharmacological Intervention on Endothelial Function, Body Composition, and Physical Functionality in Recovered COVID-19 Patients.
N/A NCT07544186 Kind: NA Apr 22, 2026
Abstract
This study aims to evaluate the impact of a non-pharmacological treatment (nutritional therapy and pulmonary rehabilitation) on endothelial function, body composition, and physical functionality in recovered COVID-19 patients.
The primary research question is: What is the effect of a non-pharmacological treatment (nutritional therapy and pulmonary rehabilitation) on endothelial function, body composition, and physical capacity in recovered COVID-19 patients, compared to those receiving conventional medical management? A nutritional treatment combined with L-citrulline supplementation (intervention group) will be compared against conventional treatment alone (control group). Both groups will undergo pulmonary rehabilitation for a 3-month follow-up.
Subjects assigned to the intervention group will be required to:
- Take 4 g of L-citrulline daily for 3 months.
- Attend an interim session at 1.5 months for review of the nutritional treatment and supplementation.
- Keep a record of each supplement intake.
Conditions: Supplemental Nutrition Assistance Program Education, Post COVID Syndrome, Endothelial Function
Interventions: L-citrulline supplementation
Mentioned entities
Related changes
Get daily alerts for ClinicalTrials.gov Studies
Daily digest delivered to your inbox.
Free. Unsubscribe anytime.
Source
About this page
Every important government, regulator, and court update from around the world. One place. Real-time. Free. Our mission
Source document text, dates, docket IDs, and authority are extracted directly from NIH.
The summary, classification, recommended actions, deadlines, and penalty information are AI-generated from the original text and may contain errors. Always verify against the source document.
Classification
Who this affects
Taxonomy
Browse Categories
Get alerts for this source
We'll email you when ClinicalTrials.gov Studies publishes new changes.
Subscribed!
Optional. Filters your digest to exactly the updates that matter to you.