Natera Patent Application on Xenotransplant Rejection Detection Methods
Summary
Natera, Inc. has filed US Patent Application US20260110032A1 disclosing methods for detecting and monitoring xenotransplant rejection by extracting and measuring cell-free DNA, RNA, or proteins derived from the xenotransplant in recipient biological samples. The methods enable rejection assessment through sequencing library preparation and whole genome sequencing analysis of donor-derived biomarkers. Transplant centers, biotech researchers, and diagnostics developers in the organ transplantation space should monitor this intellectual property filing.
“The present disclosure provides methods for preparation and analysis of biological samples of xenotransplant recipients, wherein the methods comprise extracting fragmented or intact cell-free DNA, RNA (such as mRNA or miRNA), or protein derived from sample of the xenotransplant recipient, and measuring amounts of cell-free DNA, RNA (such as mRNA or miRNA), or protein derived from the xenotransplant enables assessment of xenotransplant rejection.”
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GovPing monitors USPTO Patent Applications - Biotech (C12N) for new healthcare & life sciences regulatory changes. Every update since tracking began is archived, classified, and available as free RSS or email alerts — 263 changes logged to date.
What changed
Natera, Inc. filed US Patent Application US20260110032A1 covering methods for detecting and monitoring xenotransplant rejection through analysis of donor-derived cell-free DNA, RNA (including mRNA or miRNA), or protein biomarkers extracted from recipient biological samples. The detection of cell-free DNA or RNA may be performed by preparing sequencing libraries and performing whole genome sequencing. The application was filed on September 27, 2023, and published April 23, 2026.
Affected parties include transplant centers, biotechnology companies developing organ transplantation diagnostics, and clinical researchers focused on xenotransplant monitoring. While this is a patent application rather than an issued patent, companies engaged in cell-free DNA-based transplant monitoring technologies should review the scope of these claims as they advance toward potential grant.
Archived snapshot
Apr 24, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
METHODS FOR DETERMINATION AND MONITORING OF XENOTRANSPLANT REJECTION BY MEASURING NUCLEIC ACIDS OR PROTEINS DERIVED FROM THE XENOTRANSPLANT
Application US20260110032A1 Kind: A1 Apr 23, 2026
Assignee
Natera, Inc.
Inventors
Tudor Pompiliu CONSTANTIN, Bernhard ZIMMERMANN, Gabrielle HEILEK, Swee Seong WONG
Abstract
The present disclosure provides methods for preparation and analysis of biological samples of xenotransplant recipients, wherein the methods comprise extracting fragmented or intact cell-free DNA, RNA (such as mRNA or miRNA), or protein derived from sample of the xenotransplant recipient, and measuring amounts of cell-free DNA, RNA (such as mRNA or miRNA), or protein derived from the xenotransplant enables assessment of xenotransplant rejection. The detection of the cell-free DNA, or RNA may be performed by preparing sequencing libraries and performing whole genome sequencing.
CPC Classifications
C12Q 1/6883 C12N 9/226 C12N 15/1096 C12N 15/111 C12Q 1/37 C12Q 1/6806 C12Q 1/6809 C12Q 1/6848 C12Q 1/6874 C12N 2310/20 C12Q 2600/106 G01N 2333/922
Filing Date
2023-09-27
Application No.
19117608
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