Microglia From Pluripotent Stem Cells
Summary
The USPTO published patent application US20260109946A1 on April 23, 2026, covering methods and compositions for generating microglial progenitor cells and microglial cells from pluripotent stem cells. Inventors include Panagiotis Douvaras, Scott Noggle, Stephen Chang, and Valentina Fossati. The application (No. 19423436) was filed on December 17, 2025, and covers both the cell generation methods and applications including methods of treatment and drug screening.
“The present invention provides methods and compositions for the generation of microglial progenitor cells and microglial cells from pluripotent stem cells, such as embryonic stem cells and induced pluripotent stem cells.”
About this source
GovPing monitors USPTO Patent Applications - Biotech (C12N) for new healthcare & life sciences regulatory changes. Every update since tracking began is archived, classified, and available as free RSS or email alerts — 264 changes logged to date.
What changed
The USPTO published a patent application disclosing methods and compositions for generating microglial progenitor cells and microglial cells from pluripotent stem cells, including embryonic stem cells and induced pluripotent stem cells. The application also covers cells produced using such methods, methods of treatment, and methods of drug screening utilizing these cells, as well as tissue culture media, supplements, and kits.
Affected parties in the biotechnology, pharmaceutical, and cell therapy sectors should review the disclosed methods and compositions to assess potential patent landscape implications, freedom-to-operate considerations, and opportunities for licensing or alternative approach development.
Archived snapshot
Apr 23, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
MICROGLIA DERIVED FROM PLURIPOTENT STEM CELLS AND METHODS OF MAKING AND USING THE SAME
Application US20260109946A1 Kind: A1 Apr 23, 2026
Inventors
Panagiotis Douvaras, Scott Noggle, Stephen Chang, Valentina Fossati
Abstract
The present invention provides methods and compositions for the generation of microglial progenitor cells and microglial cells from pluripotent stem cells, such as embryonic stem cells and induced pluripotent stem cells. The present invention also provides cells produced using such methods, and both methods of treatment and methods of drug screening that use such cells. Also provided are various tissue culture media, tissue culture media supplements, and kits useful for the generation of human microglial progenitor cells and human microglial cells.
CPC Classifications
C12N 5/0622 A61K 35/30 C12N 5/0606 C12N 5/0618 G01N 33/5058 C12N 2500/90 C12N 2501/155 C12N 2501/22 C12N 2501/2334 C12N 2506/45
Filing Date
2025-12-17
Application No.
19423436
Named provisions
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