METABOLIC SELECTION VIA THE SERINE BIOSYNTHESIS PATHWAY
Application
US20260085327A1
Kind: A1
Mar 26, 2026
Inventors
Mary Otto, James Ravellette, David Razafsky, Jason A. Gustin, Trissa Borgschulte
Abstract
The present disclosure provides an isolated mammalian cell comprising a reduced or eliminated expression of Phosphoserine Phosphatase (PSPH). Further provided are methods for preparing such cells and methods for using such cells for the production of recombinant proteins.
CPC Classifications
C12N 15/85
C07K 16/00
C12N 5/0682
C12N 9/226
C12N 9/93
C12N 15/111
C07K 2317/31
C12N 2310/20
C12N 2510/00
C12Y 301/03003
C12Y 603/01002
C12Y 603/05004
Filing Date
2023-09-29
Application No.
19112686