Methods and Systems for Long-Range Methylation Profiling
Summary
Moonwalk Biosciences, Inc. has filed patent application US20260110025A1, published April 23, 2026, covering methods and systems for determining epigenetic profiles of cells in a cell population. The technology involves sequencing DNA molecules to provide sequence reads with methylation status, assembling contigs from overlapping sequence reads, and identifying contigs with different methylation profiles associated with different cells. The application was filed December 29, 2023, under Application No. 19144874. Biotech and pharmaceutical companies developing single-cell epigenomics tools or precision medicine diagnostics may want to review this filing for potential freedom-to-operate considerations.
“Methods for determining an epigenetic profile of a cell in a cell population are described herein.”
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What changed
Moonwalk Biosciences, Inc. filed Application US20260110025A1 on December 29, 2023, which was published on April 23, 2026. The application discloses methods for determining epigenetic profiles by sequencing DNA molecules to obtain methylation status across multiple bases, then assembling contigs from overlapping sequence reads. The technology distinguishes cells within a population based on methylation profile differences in contigs with substantially identical nucleobase sequences.
Affected parties include biotech companies developing single-cell sequencing or epigenomics platforms, diagnostic developers using methylation profiling for cancer or developmental biology applications, and research institutions conducting cell population analysis. Parties should review for potential licensing needs or freedom-to-operate concerns, particularly where methylation profiling methods overlap with existing patent portfolios in the epigenomics space.
Archived snapshot
Apr 24, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
METHODS AND SYSTEMS FOR LONG-RANGE METHYLATION PROFILING
Application US20260110025A1 Kind: A1 Apr 23, 2026
Assignee
Moonwalk Biosciences, Inc.
Inventors
Arash JAMSHIDI, Justin K. VALLEY
Abstract
Methods for determining an epigenetic profile of a cell in a cell population are described herein. The method can include sequencing DNA molecules obtained from cells in a. cell population to provide a plurality of sequence reads comprising a methylation status for a plurality of bases in each sequence read; and assembling a plurality of contigs based on the plurality of sequence reads. Sequence reads having the same nucleobase sequence and methylation statuses within overlapping portions are joined together to form the same contig. Contigs having substantially the same nucleobase sequence and different methylation profiles are identified as being associated with different cells in the cell population.
CPC Classifications
C12Q 1/6869 C12N 9/226 C12N 15/11 C12N 15/907 C12N 2310/20
Filing Date
2023-12-29
Application No.
19144874
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