Subclinical Atherosclerosis in Juvenile Systemic Lupus Erythematosus
Summary
A new observational study (NCT07545408) registered on ClinicalTrials.gov will evaluate subclinical atherosclerosis in children and adolescents with juvenile systemic lupus erythematosus (SLE) by measuring carotid intima-media thickness (CIMT), and will assess associations with both traditional cardiovascular risk factors (dyslipidemia, hypertension, obesity) and non-traditional disease-related risk factors (disease activity, lupus nephritis, corticosteroid dose, disease duration). The study is listed as observational with an anticipated end date.
“The aim of this study is to evaluate subclinical atherosclerosis in children and adolescents with juvenile SLE by measuring carotid intima-media thickness (CIMT), and to determine its associations with traditional cardiovascular risk factors (dyslipidemia, hypertension, obesity) and non-traditional disease-related risk factors (disease activity, lupus nephritis, corticosteroid dose, disease duration).”
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What changed
A new observational clinical trial registration was published on ClinicalTrials.gov for a study investigating subclinical atherosclerosis in juvenile systemic lupus erythematosus (SLE) patients. The study will measure carotid intima-media thickness (CIMT) as a marker of early atherosclerosis and will examine associations with traditional cardiovascular risk factors including dyslipidemia, hypertension, and obesity, as well as disease-specific factors such as disease activity, lupus nephritis, corticosteroid dose, and disease duration.
Affected parties include clinical investigators in pediatric rheumatology and cardiovascular epidemiology, as well as patients with juvenile SLE who may be eligible for enrollment. The study does not create compliance obligations but may inform future clinical guidance on cardiovascular risk monitoring in this patient population.
Archived snapshot
Apr 22, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Subclinical Atherosclerosis in Juvenile Systemic Lupus Erythematosus
Observational NCT07545408 Kind: OBSERVATIONAL Apr 22, 2026
Abstract
The aim of this study is to evaluate subclinical atherosclerosis in children and adolescents with juvenile SLE by measuring carotid intima-media thickness (CIMT), and to determine its associations with traditional cardiovascular risk factors (dyslipidemia, hypertension, obesity) and non-traditional disease-related risk factors (disease activity, lupus nephritis, corticosteroid dose, disease duration).
Conditions: Atherosclerosis
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