ISRCTN - UK Trials

A-PATH Trial, Domestic Abuse Support, Women 60+, Recruiting

The A-PATH clinical trial (ISRCTN16469112) is a prospectively registered, multi-site, randomized controlled feasibility study evaluating an adapted psychological support intervention for women aged 60 and older affected by domestic abuse in England and Wales. The study aims to recruit 131 participants across urban and rural sites between April 2026 and March 2029, testing the acceptability and effectiveness of the adapted A-PATH programme compared to standard domestic abuse advocacy support. Ethics approval was granted on 12 March 2026 by the London Stanmore Research Ethics Committee (ref: 26/PR/0105) and the trial is currently open to recruitment.

End of Life Care Study, Rural Coastal Devon Cornwall Somerset

A new observational clinical trial has been registered on ISRCTN studying end-of-life care provision in rural and coastal communities across Devon, Cornwall and Somerset. The 28-month participatory realist evaluation is sponsored by University of Plymouth and funded by the National Institute for Health and Care Research (£167,160). The study began recruiting on 20 February 2026 with a target enrollment of 320 participants including patients, family carers and health/social care professionals, and runs until January 2028.

SAFE Study Tests Support for Autistic Families

The SAFE study (ISRCTN89355835) has been registered on the ISRCTN clinical trials registry. The randomised controlled trial will evaluate the SAFE (Systemic Autism-related Family Enabling) support package plus usual care versus usual care alone for families of autistic children aged 3-16 years with level 1 or 2 autism. The trial is sponsored by Devon Partnership NHS Trust, funded by the NIHR Health Technology Assessment Programme, and will recruit families at multiple UK sites from August 2026 through March 2029.