ISRCTN - Cancer Trials

TROPICCANA HPV-Detect Blood Test Cervical Cancer Monitoring Trial

The TROPICCANA observational cohort trial is recruiting approximately 3000 UK patients annually diagnosed with HPV-caused cervix cancer to validate the HPV-detect blood test (circulating HPV-DNA via ddPCR) as a predictor of residual disease following chemoradiotherapy. The Royal Marsden NHS Foundation Trust-sponsored study runs from January 2026 to July 2030, with ethics approval granted 26/01/2026 by South Central - Oxford A REC (ref: 26/SC/0016). Participants donate blood samples before and during treatment without additional clinical visits or altered treatment plans.

ISRCTN51391184: DNA Methylation Analysis on Self-Samples for Cervical Cancer Detection

Self-screen B.V. has registered an observational multi-center equivalence study (ISRCTN51391184) evaluating the clinical performance of the PreCursor-M Gold DNA methylation assay on self-collected vaginal specimens for cervical cancer detection. The study, approved by the Ministry of Health of Republic of Uzbekistan Ethics Committee on 09/02/2026, will recruit approximately 250 women in Tashkent, Uzbekistan to obtain 140 high-risk HPV-positive participants (70 with CIN3+ and 70 without disease or ≤CIN1). Both self-collected Floqswab samples and clinician-taken cervical smears will be tested at Amsterdam University Medical Center for equivalence comparison against the PreCursor-M+ reference method.

Respiratory-Swallow Training Trial for Head and Neck Cancer

The University of Liverpool has registered a prospective randomised controlled trial (ISRCTN12055450) evaluating respiratory-swallow training as an intervention for dysphagia in patients who have completed head and neck cancer treatment. The trial, funded by the National Institute for Health and Care Research (NIHR303061) and approved through IRAS 335217, will recruit participants from NHS sites who finished curative-intent cancer treatment at least 3 months ago. Participants will be randomised to receive up to 6 weeks of weekly swallow training with biofeedback equipment or to a control group receiving no training, with follow-up at one week and three months post-training.