In Vivo Protein Immobilization via Self-Crystallization
Summary
The USPTO has published patent application US20260109739A1, filed August 14, 2025 (Application No. 19300559), covering a system for in vivo protein immobilization via self-crystallization. Inventors are Michael CHAN, Bradley Heater, and Marianne Lee. The published application claims a novel method for immobilizing recombinantly produced proteins by entrapping them within crystals formed by co-expressed self-crystallizing proteins.
“The present invention provides a novel system for immobilizing recombinantly produced proteins by entrapping them in crystals of co-expressed proteins that are capable of self-crystallization.”
About this source
USPTO classification C07K covers peptides: short amino-acid chains that form the backbone of antibodies, hormones, vaccines, and increasingly a wider class of therapeutic modalities. Every newly published application in C07K lands in this feed, around 175 a month. Applications publish 18 months after filing, so this feed reveals what antibody engineering groups, vaccine developers, and plant biotech researchers were working on in the prior year and a half. Watch this if you compete in biologics, file freedom-to-operate analyses on antibody drug candidates, scout acquisition targets in vaccine platforms, or track protein-based agricultural biotech filings.
What changed
The USPTO has published a patent application disclosing a system for immobilizing recombinantly produced proteins in vivo by co-expressing the target proteins with proteins capable of self-crystallization, which then form crystals that entrap the target proteins. The application covers the compositions, methods of making the immobilized proteins, and methods of using them.
Parties in the biotechnology and pharmaceutical sectors developing protein-based products, enzyme systems, or biomanufacturing processes should monitor the prosecution of this application. The claimed method could have implications for enzyme immobilization in industrial processes, protein stabilization for therapeutic applications, and platform approaches to biomanufacturing involving protein immobilization.
Archived snapshot
Apr 23, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
IN VIVO IMMOBILIZATION OF PROTEINS
Application US20260109739A1 Kind: A1 Apr 23, 2026
Inventors
Michael CHAN, Bradley Heater, Marianne Lee
Abstract
The present invention provides a novel system for immobilizing recombinantly produced proteins by entrapping them in crystals of co-expressed proteins that are capable of self-crystallization. Related compositions and as well as methods of making and using the immobilized proteins are also described.
CPC Classifications
C07K 14/325 C12N 15/70 C12N 15/75 C07K 2319/00
Filing Date
2025-08-14
Application No.
19300559
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