Heparan-N-sulfatase purification via multi-mode chromatography
Summary
The USPTO published patent application US20260092264A1 on April 2, 2026, disclosing a novel method for purifying heparan-N-sulfatase using multi-mode chromatography combined with caprylate precipitation. Invented by six researchers, the method removes host cell proteins and improves purity and stability of the enzyme for potential pharmaceutical applications.
What changed
The USPTO published application US20260092264A1, disclosing a method for purifying heparan-N-sulfatase from solutions containing impurities. The method combines multi-mode chromatography to obtain an eluate, followed by caprylate precipitation to produce a purified supernatant. The claimed invention is classified under CPC codes C12N 9/14, C07K 1/165, C07K 1/30, C07K 1/34, and C12Y 310/01001, indicating applications in enzyme chemistry and protein purification.
Patent applications do not impose compliance obligations on industry. For biopharmaceutical manufacturers developing heparan-N-sulfatase-based therapeutics, this publication represents potential prior art that could affect freedom-to-operate assessments. Research and development teams working on enzyme purification processes should review the disclosed methods for potential licensing opportunities or to assess patent landscape implications.
Archived snapshot
Apr 2, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
NOVEL PROCESS FOR PURIFYING HEPARAN-N-SULFATASE
Application US20260092264A1 Kind: A1 Apr 02, 2026
Inventors
Kwanyoung KO, Dasom KIM, Sulgi YOO, Geunhye YEO, Minjung KIM, Dong Kyu JIN
Abstract
The present invention is related to a method for purifying heparan-N-sulfatase from a heparan-N-sulfatase-containing solution including at least one impurity, the method comprising performing multi-mode chromatography (MMC) to obtain an eluate; and performing caprylate precipitation to obtain a supernatant. The method according to the present invention is capable of very efficiently removing HCP (host cell proteins) and of greatly improving the purity and stability of purified heparan-N-sulfatase.
CPC Classifications
C12N 9/14 C07K 1/165 C07K 1/30 C07K 1/34 C12Y 310/01001
Filing Date
2023-09-18
Application No.
19110710
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