Fertility Restoration With Autografting of Cryopreserved Testicular Tissue
Summary
NIH registered a pilot clinical trial (NCT07542626) evaluating autologous transplantation of cryopreserved immature testicular tissue as a fertility restoration method for prepubertal boys who become azoospermic or severely oligozoospermic after gonadotoxic therapies such as chemotherapy. The study plans to enroll participants and assess the feasibility of reimplanting previously frozen tissue.
What changed
The NIH registered a new pilot clinical trial on ClinicalTrials.gov describing a fertility preservation approach for prepubertal boys facing gonadotoxic treatments. The study will evaluate transplantation of the patient's own previously cryopreserved testicular tissue as a potential method to restore fertility when surgical sperm retrieval is unsuccessful. Clinical trial registrations on ClinicalTrials.gov are informational postings and do not create compliance obligations for healthcare providers, manufacturers, or other parties. Healthcare institutions offering pediatric oncology services or fertility preservation counseling may wish to note this trial as an emerging option in the fertility preservation landscape.
Archived snapshot
Apr 21, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Fertility Restoration With Autografting of Cryopreserved Immature Testicular Tissue
N/A NCT07542626 Kind: NA Apr 21, 2026
Abstract
This is a pilot clinical trial to evaluate the feasibility and outcome of autologous transplantation of immature testicular tissue cryopreserved during childhood as a method of fertility preservation for prepubertal boys in case of gonadotoxic therapies.
Freezing of immature testicular tissue is performed since the early 2000s and a number of our patients have now reached reproductive age. In case of childwish and azoospermia in adulthood, surgical sperm retrieval is planned and if unsucessful transplantation of the patient's own cryopreserved tissue will be performed during the same surgical intervention as a fertility restoration method.
Conditions: Azoospermia or Severe Oligozoospermia, Infertility, Autologous Transplantation
Interventions: autologous transplantation of cryopreserved testicular tissue
Mentioned entities
Related changes
Get daily alerts for ClinicalTrials.gov Studies
Daily digest delivered to your inbox.
Free. Unsubscribe anytime.
Source
About this page
Every important government, regulator, and court update from around the world. One place. Real-time. Free. Our mission
Source document text, dates, docket IDs, and authority are extracted directly from NIH.
The summary, classification, recommended actions, deadlines, and penalty information are AI-generated from the original text and may contain errors. Always verify against the source document.
Classification
Who this affects
Taxonomy
Browse Categories
Get alerts for this source
We'll email you when ClinicalTrials.gov Studies publishes new changes.
Subscribed!
Optional. Filters your digest to exactly the updates that matter to you.