Fc-IL2 variant cancer therapy combination patents
Summary
USPTO published patent application US20260091062A1 by Hoffmann-La Roche Inc. covering recombinant Fc domain-IL-2 variant polypeptides combined with membrane-anchored antigen binding polypeptides for cancer treatment. The application (No. 19272092) was filed July 17, 2025, and published April 2, 2026.
What changed
Hoffmann-La Roche Inc. received USPTO publication for patent application US20260091062A1 covering combination therapy using recombinant Fc domain-IL-2 variant polypeptides with membrane-anchored antigen binding polypeptides for cancer prevention and treatment. The application claims compositions and methods classified under CPC codes including A61K 35/17, C07K 14/55, and C07K 14/705. Inventors include Diana Darowski, Stephan Gasser, Christian Klein, Simone Lang, and Dario Venetz.
This patent publication is informational only and does not impose compliance requirements. Pharmaceutical companies developing IL-2 based cancer immunotherapies should review the claims to assess potential freedom-to-operate considerations. No action is required unless the entity is actively developing competing IL-2 variant therapies that may fall within the claimed combination framework.
Archived snapshot
Apr 2, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Recombinant Fc domain - IL2 variant polypeptides and combination therapy with membrane-anchored antigen binding polypeptides
Application US20260091062A1 Kind: A1 Apr 02, 2026
Assignee
Hoffmann-La Roche Inc.
Inventors
Diana DAROWSKI, Stephan GASSER, Christian KLEIN, Simone LANG, Dario VENETZ
Abstract
The present invention relates to the combination therapy of recombinant Fc domain-IL-2 variant polypeptides with membrane-anchored antigen binding polypeptides in the prevention or treatment of cancer.
CPC Classifications
A61K 35/17 A61K 40/11 A61K 40/31 A61K 40/4217 A61K 40/4234 A61P 35/00 A61P 37/04 C07K 14/55 C07K 14/7051 C07K 14/70517 C07K 14/70535 C07K 14/7155 C12N 5/0018 A61K 2239/11 C07K 2319/30 C12N 2501/2302 C12N 2501/515
Filing Date
2025-07-17
Application No.
19272092
Named provisions
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Source
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