Fasting-Mimicking Diet in Obese Patients With Severe Periodontitis Study
ClinicalTrials.gov Studies
Summary
This pilot randomized cross-over clinical trial registered on ClinicalTrials.gov will evaluate whether a fasting-mimicking diet (FMD) administered in three 5-day cycles can improve systemic and periodontal response to non-surgical periodontal treatment in obese adults with Stage III-IV periodontitis. Participants will be assigned to either an FMD group or a control group continuing their usual diet, with a wash-out period before crossover. The study's primary outcome is reduction in serum C-reactive protein (CRP), with secondary outcomes including clinical periodontal measurements, inflammatory markers in gingival crevicular fluid, and changes in oral and gut microbiota. Findings will inform feasibility and preliminary data for a larger clinical trial.
“This study will evaluate whether a fasting-mimicking diet (FMD) can improve the systemic and periodontal response to non-surgical periodontal treatment in obese adults with severe periodontitis.”
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What changed
This document registers a new pilot randomized cross-over clinical trial on ClinicalTrials.gov (NCT07549633) evaluating a fasting-mimicking diet (FMD) as an adjunct to non-surgical periodontal therapy in obese patients with severe periodontitis. The study will administer three 5-day FMD cycles around the treatment period, assessing serum CRP as the primary endpoint along with periodontal clinical measurements and microbiota changes.
Healthcare providers and clinical investigators involved in periodontics or obesity-related inflammatory conditions should note this trial as a data source for future evidence synthesis. The study's cross-over design and multi-marker outcome set may inform protocol considerations for future dietary-intervention trials in inflammatory oral-systemic disease.
Archived snapshot
Apr 24, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Application of a Fasting-mimicking Diet in Obese Patients With Periodontitis Stage III-IV
N/A NCT07549633 Kind: NA Apr 24, 2026
Abstract
This study will evaluate whether a fasting-mimicking diet (FMD) can improve the systemic and periodontal response to non-surgical periodontal treatment in obese adults with severe periodontitis. Periodontitis is a serious inflammatory disease that damages the tissues supporting the teeth and may also contribute to inflammation elsewhere in the body. Obesity is also associated with increased systemic inflammation, which may worsen periodontal disease and affect treatment outcomes.
In this pilot randomized cross-over clinical trial, eligible participants will receive full-mouth non-surgical periodontal therapy and will be assigned either to an FMD group or to a control group continuing their usual diet. The FMD will be administered in three 5-day cycles around the periodontal treatment period. After a wash-out period, the groups will switch interventions.
The study will assess whether FMD can reduce systemic inflammation, measured primarily by serum C-reactive protein (CRP), and improve periodontal healing after treatment. Additional outcomes include clinical periodontal measurements, inflammatory markers in gingival crevicular fluid, and changes in oral and gut microbiota. Findings from this study will help determine the feasibility of this dietary approach and provide preliminary data for a larger clinical trial.
Conditions: Periodontitis (Stage 3), Periodontitis Stage IV
Interventions: Fast mimicking diet group, Normal diet group
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